Literature DB >> 3102948

Extinction of expression of immunoglobulin genes in myeloma X fibroblast somatic cell hybrids.

A Greenberg, R Ber, Z Kra-Oz, R Laskov.   

Abstract

Adherent hybrids between immunoglobulin-producing mouse myeloma cells and fibroblasts do not produce immunoglobulin polypeptide chains. These hybrids retained the actively rearranged immunoglobulin genes of the myeloma parental cells but lacked immunoglobulin heavy- and light-chain RNA transcripts. We conclude that the shutoff of immunoglobulin production in these hybrids occurs at the transcription or early processing level.

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Year:  1987        PMID： 3102948      PMCID： PMC365154          DOI： 10.1128/mcb.7.2.936-939.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  38 in total

1.  Expression of differentiated functions in hepatoma cell hybrids: IX extinction and reexpression of liver-specific enzymes in rat hepatoma-Chinese hamster fibroblast hybrids.

Authors:  M C Weiss; R S Sparkes; R Bertolotti
Journal:  Somatic Cell Genet       Date:  1975-01

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Gene activation in somatic nuclei after injection into amphibian oocytes.

Authors:  E M De Robertis; J B Gurdon
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

Review 4.  Use of somatic cell hybrids for analysis of the differentiated state.

Authors:  F M Davis; E A Adelberg
Journal:  Bacteriol Rev       Date:  1973-06

Review 5.  Gene expression in somatic cell hybrids.

Authors:  R L Davidson
Journal:  Annu Rev Genet       Date:  1974       Impact factor: 16.830

6.  Expression of differentiated functions in hepatoma cell hybrids. VI. Extinction and re-expression of liver alcohol dehydrogenase.

Authors:  R Bertolotti; M C Weiss
Journal:  Biochimie       Date:  1972       Impact factor: 4.079

7.  Expression of differentiated functions in hepatoma cell hybrids. I. Tyrosine aminotransferase in hepatoma-fibroblast hybrids.

Authors:  J A Schneider; M C Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1971-01       Impact factor: 11.205

8.  Suppression of immunoglobulin synthesis by cellular hybridization.

Authors:  P Coffino; B Knowles; S G Nathenson; M D Scharff
Journal:  Nat New Biol       Date:  1971-05-19

9.  Regulation of immunoglobulin expression in mouse myeloma cells.

Authors:  D H Margulies; W Cieplinski; B Dharmgrongartama; M L Gefter; S L Morrison; T Kelly; M D Scharff
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

10.  Cloning of mouse myeloma cells and detection of rare variants.

Authors:  P Coffino; R Baumal; R Laskov; M D Scharff
Journal:  J Cell Physiol       Date:  1972-06       Impact factor: 6.384
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  9 in total

1.  Novel regulation of transcription initiation of the peptide IX gene of adenovirus 2.

Authors:  T Matsui
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

2.  Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

Authors:  J L Imler; C Lemaire; C Wasylyk; B Wasylyk
Journal:  Mol Cell Biol       Date:  1987-07       Impact factor: 4.272

3.  The octamer/mu E4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma x T-lymphoma hybrids.

Authors:  L Shen; S Lieberman; L A Eckhardt
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

4.  Host cell-dependent regulation of growth transformation-associated Epstein-Barr virus antigens in somatic cell hybrids.

Authors:  B Contreras-Salazar; G Klein; M G Masucci
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

5.  Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor.

Authors:  Y Bergman; B Strich; H Sharir; R Ber; R Laskov
Journal:  EMBO J       Date:  1990-03       Impact factor: 11.598

6.  A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene.

Authors:  V De Simone; R Cortese
Journal:  Nucleic Acids Res       Date:  1989-11-25       Impact factor: 16.971

7.  Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

Authors:  D M Zaller; H Yu; L A Eckhardt
Journal:  Mol Cell Biol       Date:  1988-05       Impact factor: 4.272

8.  Extinction of T cell receptor alpha-chain gene expression accompanied by loss of the lymphoid enhancer-binding factor 1 (LEF-1) in murine somatic cell hybrids.

Authors:  T Yamada; Y Hitomi; K Shimizu; M Ohki; T Oikawa
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

9.  Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma-fibroblast hybrid cells.

Authors:  S Junker; V Nielsen; P Matthias; D Picard
Journal:  EMBO J       Date:  1988-10       Impact factor: 11.598
  9 in total

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