Literature DB >> 3037999

Monocyclic and tricyclic analogs of quinolones: mechanism of action.

N H Georgopapadakou, B A Dix, P Angehrn, A Wick, G L Olson.   

Abstract

The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity.

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Year:  1987        PMID： 3037999      PMCID： PMC174788          DOI： 10.1128/AAC.31.4.614

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  DNA gyrase on the bacterial chromosome: DNA cleavage induced by oxolinic acid.

Authors:  M Snyder; K Drlica
Journal:  J Mol Biol       Date:  1979-06-25       Impact factor: 5.469

2.  DNA gyrase: an enzyme that introduces superhelical turns into DNA.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; H A Nash
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

3.  DNA gyrase action involves the introduction of transient double-strand breaks into DNA.

Authors:  K Mizuuchi; L M Fisher; M H O'Dea; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

4.  Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA.

Authors:  Y C Tse; K Kirkegaard; J C Wang
Journal:  J Biol Chem       Date:  1980-06-25       Impact factor: 5.157

5.  Model for regulation of Escherichia coli DNA repair functions.

Authors:  L J Gudas; A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

Review 6.  DNA topoisomerases.

Authors:  M Gellert
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

7.  Replication and repair of DNA in cells of Escherichia coli treated with toluene.

Authors:  R E Moses; C C Richardson
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

8.  Replication of Escherichia coli DNA in vitro: inhibition by oxolinic acid.

Authors:  W L Staudenbauer
Journal:  Eur J Biochem       Date:  1976-03-01

9.  Ro 13-9904, a long-acting broad-spectrum cephalosporin: in vitro and in vivo studies.

Authors:  P Angehrn; P J Probst; R Reiner; R L Then
Journal:  Antimicrob Agents Chemother       Date:  1980-12       Impact factor: 5.191

10.  MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.

Authors:  W A GOSS; W H DEITZ; T M COOK
Journal:  J Bacteriol       Date:  1965-04       Impact factor: 3.490
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  8 in total

Review 1.  Structure-activity relationships of the fluoroquinolones.

Authors:  D T Chu; P B Fernandes
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191

2.  Association between early inhibition of DNA synthesis and the MICs and MBCs of carboxyquinolone antimicrobial agents for wild-type and mutant [gyrA nfxB(ompF) acrA] Escherichia coli K-12.

Authors:  R T Chow; T J Dougherty; H S Fraimow; E Y Bellin; M H Miller
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

Review 3.  Classification and structure-activity relationships of fluoroquinolones.

Authors:  A Bryskier; J F Chantot
Journal:  Drugs       Date:  1995       Impact factor: 9.546

4.  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli.

Authors:  N H Georgopapadakou; A Bertasso
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

5.  Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I.

Authors:  X Tabary; N Moreau; C Dureuil; F Le Goffic
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191

Review 6.  Fluoroquinolone antimicrobial agents.

Authors:  J S Wolfson; D C Hooper
Journal:  Clin Microbiol Rev       Date:  1989-10       Impact factor: 26.132

7.  Quinolone accumulation in Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

Authors:  C McCaffrey; A Bertasso; J Pace; N H Georgopapadakou
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

8.  Reliable Target Prediction of Bioactive Molecules Based on Chemical Similarity Without Employing Statistical Methods.

Authors:  Abed Forouzesh; Sadegh Samadi Foroushani; Fatemeh Forouzesh; Eskandar Zand
Journal:  Front Pharmacol       Date:  2019-07-26       Impact factor: 5.810
  8 in total

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