Literature DB >> 770163

Replication of Escherichia coli DNA in vitro: inhibition by oxolinic acid.

W L Staudenbauer.   

Abstract

Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates. It is about 10-fold more active than the structurally related nalidixic acid. Both drugs have no effect on the ATP-independent DNA repair, but interfere to some extent with RNA synthesis in permeable cells. They appear to interact with the same target since spontaneous nalidixic-acid-resistant mutants of nalA phenotype are also resistant to oxolinic acid. Full sensitivity to oxolinic acid can be conferred to lysates from resistant cells by addition of extracts from sensitive cells.

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Year:  1976        PMID： 770163     DOI： 10.1111/j.1432-1033.1976.tb10183.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  21 in total

1.  Differential sensitivity of gene expression in vitro to inhibitors of DNA gyrase.

Authors:  H L Yang; K Heller; M Gellert; G Zubay
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage lambda.

Authors:  J B Hays; S Boehmer
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

3.  DNA-damaging activity of patulin in Escherichia coli.

Authors:  K S Lee; R J Röschenthaler
Journal:  Appl Environ Microbiol       Date:  1986-11       Impact factor: 4.792

Review 4.  Linkage map of Escherichia coli K-12, edition 10: the traditional map.

Authors:  M K Berlyn
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

5.  Avian myeloblastosis virus reverse transcriptase inhibition by nalidixic acid.

Authors:  H Aoyama
Journal:  Mol Cell Biochem       Date:  1991-12-11       Impact factor: 3.396

6.  Initiation of plasmid R1 replication in vitro is independent of transcription by host RNA polymerase.

Authors:  R Diaz; S Ortega
Journal:  Nucleic Acids Res       Date:  1984-07-11       Impact factor: 16.971

7.  Initiation of DNA replication in Bacillus subtilis. V. Role of DNA gyrase and superhelical structure in initiation.

Authors:  N Ogasawara; M Seiki; H Yoshikawa
Journal:  Mol Gen Genet       Date:  1981

8.  Escherichia coli DNA synthesis in vitro: insensitivity of ATP-dependent DNA repair to inhibition by novobiocin.

Authors:  P K Schneck; W L Staudenbauer
Journal:  Nucleic Acids Res       Date:  1977-06       Impact factor: 16.971

9.  Replication of the ampicillin resistance plasmid RSF1030 in extracts of Escherichia coli: separation of the replication cycle into early and late stages.

Authors:  W L Staudenbauer
Journal:  Mol Gen Genet       Date:  1977-11-04

10.  Replication of small plasmids in extracts of Escherichia coli.

Authors:  W L Staudenbauer
Journal:  Mol Gen Genet       Date:  1976-06-15
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