Literature DB >> 6246508

DNA gyrase action involves the introduction of transient double-strand breaks into DNA.

K Mizuuchi, L M Fisher, M H O'Dea, M Gellert.   

Abstract

DNA gyrase from Escherichia coli, in the presence of ATP, can both separate catenated DNA circles and unknot knotted DNA. Both these reactions require passage of a DNA segment through a transient double-strand break in DNA. Evidence that transient double-strand breaks are also involved in the supercoiling and relaxing activities of DNA gyrase is derived from experiments showing that the linking number of circular DNA is changed in steps of two. A mechanism is proposed for the action of the enzyme.

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Year:  1980        PMID： 6246508      PMCID： PMC348605          DOI： 10.1073/pnas.77.4.1847

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme.

Authors:  L F Liu; J C Wang
Journal:  Cell       Date:  1978-11       Impact factor: 41.582

2.  Integrative recombination of bacteriophage lambda: in vitro study of the intermolecular reaction.

Authors:  K Mizuuchi; M Mizuuchi
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1979

3.  DNA gyrase and DNA supercoiling.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; H Ohmori; J Tomizawa
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1979

4.  Restriction assay for integrative recombination of bacteriophage lambda DNA in vitro: requirement for closed circular DNA substrate.

Authors:  K Mizuuchi; H A Nash
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

5.  The problems of eukaryotic and prokaryotic DNA packaging and in vivo conformation posed by superhelix density heterogeneity.

Authors:  M Shure; D E Pulleyblank; J Vinograd
Journal:  Nucleic Acids Res       Date:  1977       Impact factor: 16.971

6.  Site-specific recombination in bacteriophage lambda.

Authors:  J Engler; R B Inman
Journal:  J Mol Biol       Date:  1977-06-25       Impact factor: 5.469

7.  Site-specific cleavage of DNA by E. coli DNA gyrase.

Authors:  A Morrison; N R Cozzarelli
Journal:  Cell       Date:  1979-05       Impact factor: 41.582

8.  Replication of colicin E1 plasmid DNA in cell extracts.

Authors:  Y Sakakibara; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

9.  The bacteriophage lambda int gene product. A filter assay for genetic recombination, purification of int, and specific binding to DNA.

Authors:  Y Kikuchi; H A Nash
Journal:  J Biol Chem       Date:  1978-10-25       Impact factor: 5.157

10.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205
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  98 in total

1.  Topoisomerase IV, alone, unknots DNA in E. coli.

Authors:  R W Deibler; S Rahmati; E L Zechiedrich
Journal:  Genes Dev       Date:  2001-03-15       Impact factor: 11.361

2.  Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones.

Authors:  X S Pan; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

3.  The mechanism of type IA topoisomerases.

Authors:  N H Dekker; V V Rybenkov; M Duguet; N J Crisona; N R Cozzarelli; D Bensimon; V Croquette
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-07       Impact factor: 11.205

4.  Deformation of DNA during site-specific recombination of bacteriophage lambda: replacement of IHF protein by HU protein or sequence-directed bends.

Authors:  S D Goodman; S C Nicholson; H A Nash
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

5.  Computational analysis of DNA gyrase action.

Authors:  Alexander Vologodskii
Journal:  Biophys J       Date:  2004-08-31       Impact factor: 4.033

6.  Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.

Authors:  F L Alovero; X S Pan; J E Morris; R H Manzo; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

7.  Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.

Authors:  X S Pan; G Yague; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

8.  Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones.

Authors:  Xiao-Su Pan; Penelope J Hamlyn; Raquel Talens-Visconti; Fabiana L Alovero; Ruben H Manzo; L Mark Fisher
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

9.  Inhibition of recovery from potentially lethal damage by chemicals in Chinese hamster V79 A cells.

Authors:  A Kumar; J Kiefer; E Schneider; N E Crompton
Journal:  Radiat Environ Biophys       Date:  1985       Impact factor: 1.925

10.  DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.

Authors:  X S Pan; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191
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