Literature DB >> 30365391

Why Is ORMDL3 on Chromosome 17q21 Highly Linked to Asthma?

Marina Miller1, David H Broide1.   

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Year:  2019        PMID： 30365391      PMCID： PMC6376625          DOI： 10.1164/rccm.201810-1941ED

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN： 1073-449X            Impact factor:   21.405


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  19 in total

1.  Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

Authors:  Dominique J Verlaan; Soizik Berlivet; Gary M Hunninghake; Anne-Marie Madore; Mathieu Larivière; Sanny Moussette; Elin Grundberg; Tony Kwan; Manon Ouimet; Bing Ge; Rose Hoberman; Marcin Swiatek; Joana Dias; Kevin C L Lam; Vonda Koka; Eef Harmsen; Manuel Soto-Quiros; Lydiana Avila; Juan C Celedón; Scott T Weiss; Ken Dewar; Daniel Sinnett; Catherine Laprise; Benjamin A Raby; Tomi Pastinen; Anna K Naumova
Journal:  Am J Hum Genet       Date:  2009-09       Impact factor: 11.025

2.  Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.

Authors:  Yury A Bochkov; Kelly Watters; Shamaila Ashraf; Theodor F Griggs; Mark K Devries; Daniel J Jackson; Ann C Palmenberg; James E Gern
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

3.  Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Authors:  Clement Oyeniran; Jamie L Sturgill; Nitai C Hait; Wei-Ching Huang; Dorit Avni; Michael Maceyka; Jason Newton; Jeremy C Allegood; Alison Montpetit; Daniel H Conrad; Sheldon Milstien; Sarah Spiegel
Journal:  J Allergy Clin Immunol       Date:  2015-04-02       Impact factor: 10.793

4.  Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide.

Authors:  Marina Miller; Peter Rosenthal; Andrew Beppu; Ruth Gordillo; David H Broide
Journal:  J Allergy Clin Immunol       Date:  2016-11-05       Impact factor: 10.793

5.  ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.

Authors:  Marina Miller; Arvin B Tam; Jae Youn Cho; Taylor A Doherty; Alexa Pham; Naseem Khorram; Peter Rosenthal; James L Mueller; Hal M Hoffman; Maho Suzukawa; Maho Niwa; David H Broide
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-24       Impact factor: 11.205

6.  Blocking intercellular adhesion molecule-1 on human epithelial cells decreases respiratory syncytial virus infection.

Authors:  A K Behera; H Matsuse; M Kumar; X Kong; R F Lockey; S S Mohapatra
Journal:  Biochem Biophys Res Commun       Date:  2001-01-12       Impact factor: 3.575

7.  ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48.

Authors:  Sung Gil Ha; Xiao Na Ge; Nooshin S Bahaie; Bit Na Kang; Amrita Rao; Savita P Rao; P Sriramarao
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

Review 8.  A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.

Authors:  Michelle M Stein; Emma E Thompson; Nathan Schoettler; Britney A Helling; Kevin M Magnaye; Catherine Stanhope; Catherine Igartua; Andréanne Morin; Charles Washington; Dan Nicolae; Klaus Bønnelykke; Carole Ober
Journal:  J Allergy Clin Immunol       Date:  2018-01-04       Impact factor: 10.793

9.  Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus.

Authors:  Parul H Kothari; Weiliang Qiu; Damien C Croteau-Chonka; Fernando D Martinez; Andrew H Liu; Robert F Lemanske; Carole Ober; Jerry A Krishnan; Dan L Nicolae; Kathleen C Barnes; Stephanie J London; Albino Barraza-Villarreal; Steven R White; Edward T Naureckas; Joshua Millstein; W James Gauderman; Frank D Gilliland; Vincent J Carey; Scott T Weiss; Benjamin A Raby
Journal:  J Allergy Clin Immunol       Date:  2018-01-31       Impact factor: 10.793

10.  Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

Authors:  Miriam F Moffatt; Michael Kabesch; Liming Liang; Anna L Dixon; David Strachan; Simon Heath; Martin Depner; Andrea von Berg; Albrecht Bufe; Ernst Rietschel; Andrea Heinzmann; Burkard Simma; Thomas Frischer; Saffron A G Willis-Owen; Kenny C C Wong; Thomas Illig; Christian Vogelberg; Stephan K Weiland; Erika von Mutius; Gonçalo R Abecasis; Martin Farrall; Ivo G Gut; G Mark Lathrop; William O C Cookson
Journal:  Nature       Date:  2007-07-04       Impact factor: 49.962
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  6 in total

1.  The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D.

Authors:  Rachel S Kelly; Bo L Chawes; Feng Guo; Li Zhang; Kevin Blighe; Augusto A Litonjua; Benjamin A Raby; Bruce D Levy; Daniela Rago; Jakob Stokholm; Klaus Bønnelykke; Hans Bisgaard; Xiaobo Zhou; Jessica A Lasky-Su; Scott T Weiss
Journal:  Eur Respir J       Date:  2019-10-24       Impact factor: 16.671

Review 2.  Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles.

Authors:  Tracy Augustine; Mohammad Ameen Al-Aghbar; Moza Al-Kowari; Meritxell Espino-Guarch; Nicholas van Panhuys
Journal:  Front Immunol       Date:  2022-05-25       Impact factor: 8.786

3.  Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium.

Authors:  Feng Guo; Yuan Hao; Li Zhang; Damien C Croteau-Chonka; Derek Thibault; Parul Kothari; Lijia Li; Bruce D Levy; Xiaobo Zhou; Benjamin A Raby
Journal:  Am J Respir Cell Mol Biol       Date:  2022-06       Impact factor: 7.748

4.  SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium.

Authors:  Soyeon Kim; Erick Forno; Qi Yan; Yale Jiang; Rong Zhang; Nadia Boutaoui; Edna Acosta-Pérez; Glorisa Canino; Wei Chen; Juan C Celedón
Journal:  Eur Respir J       Date:  2020-04-03       Impact factor: 16.671

5.  CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions.

Authors:  William D Stuart; Minzhe Guo; Iris M Fink-Baldauf; Alan M Coleman; John P Clancy; Marcus A Mall; Foong-Yen Lim; John J Brewington; Yutaka Maeda
Journal:  NAR Genom Bioinform       Date:  2020-05-25

6.  Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.

Authors:  Hongsheng Gui; Albert M Levin; Donglei Hu; Patrick Sleiman; Shujie Xiao; Angel C Y Mak; Mao Yang; Andrea J Barczak; Scott Huntsman; Celeste Eng; Samantha Hochstadt; Ellen Zhang; Kyle Whitehouse; Samantha Simons; Whitney Cabral; Sami Takriti; Gonçalo Abecasis; Thomas W Blackwell; Hyun Min Kang; Deborah A Nickerson; Soren Germer; David E Lanfear; Frank Gilliland; W James Gauderman; Rajesh Kumar; David J Erle; Fernando D Martinez; Hakon Hakonarson; Esteban G Burchard; L Keoki Williams
Journal:  Am J Respir Crit Care Med       Date:  2021-02-15       Impact factor: 21.405
  6 in total

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