Literature DB >> 27826095

Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide.

Marina Miller1, Peter Rosenthal1, Andrew Beppu1, Ruth Gordillo2, David H Broide3.   

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Year:  2016        PMID： 27826095      PMCID： PMC5385289          DOI： 10.1016/j.jaci.2016.08.053

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


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  20 in total

1.  Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma.

Authors:  A J Ammit; A T Hastie; L C Edsall; R K Hoffman; Y Amrani; V P Krymskaya; S A Kane; S P Peters; R B Penn; S Spiegel; R A Panettieri
Journal:  FASEB J       Date:  2001-05       Impact factor: 5.191

2.  Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

Authors:  Dominique J Verlaan; Soizik Berlivet; Gary M Hunninghake; Anne-Marie Madore; Mathieu Larivière; Sanny Moussette; Elin Grundberg; Tony Kwan; Manon Ouimet; Bing Ge; Rose Hoberman; Marcin Swiatek; Joana Dias; Kevin C L Lam; Vonda Koka; Eef Harmsen; Manuel Soto-Quiros; Lydiana Avila; Juan C Celedón; Scott T Weiss; Ken Dewar; Daniel Sinnett; Catherine Laprise; Benjamin A Raby; Tomi Pastinen; Anna K Naumova
Journal:  Am J Hum Genet       Date:  2009-09       Impact factor: 11.025

3.  Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Authors:  Clement Oyeniran; Jamie L Sturgill; Nitai C Hait; Wei-Ching Huang; Dorit Avni; Michael Maceyka; Jason Newton; Jeremy C Allegood; Alison Montpetit; Daniel H Conrad; Sheldon Milstien; Sarah Spiegel
Journal:  J Allergy Clin Immunol       Date:  2015-04-02       Impact factor: 10.793

4.  Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.

Authors:  Xiaoguang Sun; Shwu-Fan Ma; Michael S Wade; Carlos Flores; Maria Pino-Yanes; Jaideep Moitra; Carole Ober; Rick Kittles; Aliya N Husain; Jean G Ford; Joe G N Garcia
Journal:  J Allergy Clin Immunol       Date:  2010-07-10       Impact factor: 10.793

5.  Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice.

Authors:  Mohammad Reza Hojjati; Zhiqiang Li; Xian-Cheng Jiang
Journal:  Biochim Biophys Acta       Date:  2005-08-24

6.  A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Authors:  Megan M Price; Carole A Oskeritzian; Yves T Falanga; Kuzhuvelil B Harikumar; Jeremy C Allegood; Sergio E Alvarez; Daniel Conrad; John J Ryan; Sheldon Milstien; Sarah Spiegel
Journal:  J Allergy Clin Immunol       Date:  2012-08-30       Impact factor: 10.793

7.  ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.

Authors:  Marina Miller; Arvin B Tam; Jae Youn Cho; Taylor A Doherty; Alexa Pham; Naseem Khorram; Peter Rosenthal; James L Mueller; Hal M Hoffman; Maho Suzukawa; Maho Niwa; David H Broide
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-24       Impact factor: 11.205

Review 8.  Regulation of macrophage function by sphingosine-1-phosphate.

Authors:  Andreas Weigert; Nicole Weis; Bernhard Brüne
Journal:  Immunobiology       Date:  2009-07-21       Impact factor: 3.144

9.  ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Authors:  Marina Miller; Peter Rosenthal; Andrew Beppu; James L Mueller; Hal M Hoffman; Arvin B Tam; Taylor A Doherty; Matthew D McGeough; Carla A Pena; Maho Suzukawa; Maho Niwa; David H Broide
Journal:  J Immunol       Date:  2014-03-12       Impact factor: 5.422

10.  Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

Authors:  Miriam F Moffatt; Michael Kabesch; Liming Liang; Anna L Dixon; David Strachan; Simon Heath; Martin Depner; Andrea von Berg; Albrecht Bufe; Ernst Rietschel; Andrea Heinzmann; Burkard Simma; Thomas Frischer; Saffron A G Willis-Owen; Kenny C C Wong; Thomas Illig; Christian Vogelberg; Stephan K Weiland; Erika von Mutius; Gonçalo R Abecasis; Martin Farrall; Ivo G Gut; G Mark Lathrop; William O C Cookson
Journal:  Nature       Date:  2007-07-04       Impact factor: 49.962
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  25 in total

1.  Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?

Authors:  Marina Miller; Christine Vuong; Meghan Farrell Garcia; Peter Rosenthal; Sudipta Das; Ning Weng; Alexa Pham; Yu Jin Kim; David H Broide
Journal:  J Allergy Clin Immunol       Date:  2018-04-28       Impact factor: 10.793

2.  Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells.

Authors:  Yiping Liu; Yury A Bochkov; Jens C Eickhoff; Tianchen Hu; Nicholas A Zumwalde; Jin Wen Tan; Christopher Lopez; Paul S Fichtinger; Thiruchelvi R Reddy; Katherine A Overmyer; Jennifer E Gumperz; Joshua Coon; Sameer K Mathur; James E Gern; Judith A Smith
Journal:  Am J Respir Cell Mol Biol       Date:  2020-06       Impact factor: 6.914

3.  Why Is ORMDL3 on Chromosome 17q21 Highly Linked to Asthma?

Authors:  Marina Miller; David H Broide
Journal:  Am J Respir Crit Care Med       Date:  2019-02-15       Impact factor: 21.405

4.  Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes.

Authors:  Jennie G Ono; Benjamin I Kim; Yize Zhao; Paul J Christos; Yohannes Tesfaigzi; Tilla S Worgall; Stefan Worgall
Journal:  J Clin Invest       Date:  2020-02-03       Impact factor: 14.808

Review 5.  Mechanisms of non-type 2 asthma.

Authors:  Stephanie N Hudey; Dennis K Ledford; Juan Carlos Cardet
Journal:  Curr Opin Immunol       Date:  2020-11-04       Impact factor: 7.486

6.  Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

Authors:  Marina Miller; Arvin B Tam; James L Mueller; Peter Rosenthal; Andrew Beppu; Ruth Gordillo; Matthew D McGeough; Christine Vuong; Taylor A Doherty; Hal M Hoffman; Maho Niwa; David H Broide
Journal:  J Immunol       Date:  2017-03-08       Impact factor: 5.422

7.  Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase.

Authors:  Hsueh-Chun Wang; Tzu-Hsuan Wong; Li-Ting Wang; Hsiang-Han Su; Hsiu-Yueh Yu; Ai-Hsuan Wu; Yu-Chun Lin; Hua-Ling Chen; Jau-Ling Suen; Shih-Hsien Hsu; Li-Chen Chen; Yufeng Zhou; Shau-Ku Huang
Journal:  Cell Mol Immunol       Date:  2018-03-23       Impact factor: 11.530

8.  Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.

Authors:  Cynthia Kanagaratham; Victoria Chiwara; Bianca Ho; Sanny Moussette; Mina Youssef; David Venuto; Lucie Jeannotte; Guillaume Bourque; Juan Bautista de Sanctis; Danuta Radzioch; Anna K Naumova
Journal:  Mamm Genome       Date:  2018-03-13       Impact factor: 2.957

Review 9.  ORMDL3 and allergic asthma: From physiology to pathology.

Authors:  Briana James; Sheldon Milstien; Sarah Spiegel
Journal:  J Allergy Clin Immunol       Date:  2019-07-31       Impact factor: 10.793

10.  Metabolomics in the prevention and management of asthma.

Authors:  Zhaozhong Zhu; Carlos A Camargo; Kohei Hasegawa
Journal:  Expert Rev Respir Med       Date:  2019-10-09       Impact factor: 3.772
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