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Literature DB >> 30361853

Condensin action and compaction.

Matthew Robert Paul^1,2, Andreas Hochwagen³, Sevinç Ercan^4,5.

Abstract

Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

Entities: Chemical

Keywords: Chromosome interactions; Chromosome segregation; Clustering; Condensin; Genome organization; SMC complexes; TADs; Transcription; gene expression; rDNA; tRNA

Mesh：

Substances：

Year: 2018 PMID： 30361853 PMCID： PMC6421088 DOI： 10.1007/s00294-018-0899-4

Source DB: PubMed Journal: Curr Genet ISSN： 0172-8083 Impact factor: 3.886

120 in total

Review 1. Compacting DNA during the interphase: condensin maintains rDNA integrity.

Authors: Chi Kwan Tsang; Yuehua Wei; X F Steven Zheng
Journal: Cell Cycle Date: 2007-07-11 Impact factor: 4.534

2. Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.

Authors: Xindan Wang; Hugo B Brandão; Tung B K Le; Michael T Laub; David Z Rudner
Journal: Science Date: 2017-02-03 Impact factor: 47.728

3. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.

Authors: Ryu-Suke Nozawa; Koji Nagao; Ken-Taro Igami; Sachiko Shibata; Natsuko Shirai; Naohito Nozaki; Takashi Sado; Hiroshi Kimura; Chikashi Obuse
Journal: Nat Struct Mol Biol Date: 2013-03-31 Impact factor: 15.369

4. Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

Authors: Andrew T Schuster; Craig R Homer; Jacqueline R Kemp; Kourtney P Nickerson; Emily Deutschman; Yeojung Kim; Gail West; Tammy Sadler; Eleni Stylianou; Dawid Krokowski; Maria Hatzoglou; Carol de la Motte; Brian P Rubin; Claudio Fiocchi; Christine McDonald; Michelle S Longworth
Journal: Gastroenterology Date: 2015-02-18 Impact factor: 22.682

5. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes.

Authors: Rebecca A Haeusler; Matthew Pratt-Hyatt; Paul D Good; Theresa A Gipson; David R Engelke
Journal: Genes Dev Date: 2008-08-15 Impact factor: 11.361

6. Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence.

Authors: Sarah G Swygert; Seungsoo Kim; Xiaoying Wu; Tianhong Fu; Tsung-Han Hsieh; Oliver J Rando; Robert N Eisenman; Jay Shendure; Jeffrey N McKnight; Toshio Tsukiyama
Journal: Mol Cell Date: 2018-12-27 Impact factor: 17.970

7. Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation.

Authors: Wenbo Li; Yiren Hu; Soohwan Oh; Qi Ma; Daria Merkurjev; Xiaoyuan Song; Xiang Zhou; Zhijie Liu; Bogdan Tanasa; Xin He; Aaron Yun Chen; Kenny Ohgi; Jie Zhang; Wen Liu; Michael G Rosenfeld
Journal: Mol Cell Date: 2015-07-09 Impact factor: 17.970

8. Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Authors: T Hirano; S Funahashi; T Uemura; M Yanagida
Journal: EMBO J Date: 1986-11 Impact factor: 11.598

9. Compaction and segregation of sister chromatids via active loop extrusion.

Authors: Anton Goloborodko; Maxim V Imakaev; John F Marko; Leonid Mirny
Journal: Elife Date: 2016-05-18 Impact factor: 8.140

Review 10. Taking cohesin and condensin in context.

Authors: Kobe C Yuen; Jennifer L Gerton
Journal: PLoS Genet Date: 2018-01-25 Impact factor: 5.917

15 in total

1. Nucleosomes effectively shield DNA from radiation damage in living cells.

Authors: Francesca Brambilla; Jose Manuel Garcia-Manteiga; Emanuele Monteleone; Lena Hoelzen; Angelica Zocchi; Alessandra Agresti; Marco E Bianchi
Journal: Nucleic Acids Res Date: 2020-09-18 Impact factor: 16.971

2. Binding of an X-Specific Condensin Correlates with a Reduction in Active Histone Modifications at Gene Regulatory Elements.

Authors: Lena Annika Street; Ana Karina Morao; Lara Heermans Winterkorn; Chen-Yu Jiao; Sarah Elizabeth Albritton; Mohammed Sadic; Maxwell Kramer; Sevinç Ercan
Journal: Genetics Date: 2019-05-22 Impact factor: 4.562

Condensin action and compaction.

Review 1. Compacting DNA during the interphase: condensin maintains rDNA integrity.

2. Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.

3. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.

4. Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

5. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes.

6. Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence.

7. Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation.

8. Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

9. Compaction and segregation of sister chromatids via active loop extrusion.

Review 10. Taking cohesin and condensin in context.

1. Nucleosomes effectively shield DNA from radiation damage in living cells.

2. Binding of an X-Specific Condensin Correlates with a Reduction in Active Histone Modifications at Gene Regulatory Elements.

3. The yeast 2-micron plasmid Rep2 protein has Rep1-independent partitioning function.

4. NCAPH is a prognostic biomarker and associated with immune infiltrates in lung adenocarcinoma.

5. Shaping the genome via lengthwise compaction, phase separation, and lamina adhesion.

Review 6. Unraveling quiescence-specific repressive chromatin domains.

Review 7. Structural insights into DNA loop extrusion by SMC protein complexes.

8. Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons.

Review 9. SMC complexes organize the bacterial chromosome by lengthwise compaction.

10. Condensin minimizes topoisomerase II-mediated entanglements of DNA in vivo.