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Literature DB >> 3035555

Genomic organization of the mouse T-cell receptor beta-chain gene family.

Abstract

We have combined three different methods, deletion mapping of T-cell lines, field-inversion gel electrophoresis, and the restriction mapping of a cosmid clone, to construct a physical map of the murine T-cell receptor beta-chain gene family. We have mapped 19 variable (V beta) gene segments and the two clusters of diversity (D beta) and joining (J beta) gene segments and constant (C beta) genes. These members of the beta-chain gene family span approximately equal to 450 kilobases of DNA, excluding one potential gap in the DNA fragment alignments.

Entities: Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3035555 PMCID： PMC304973 DOI： 10.1073/pnas.84.11.3846

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction.

Authors: J Goverman; K Minard; N Shastri; T Hunkapiller; D Hansburg; E Sercarz; L Hood
Journal: Cell Date: 1985-04 Impact factor: 41.582

2. Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.

Authors: Y H Sun; R S Goodenow; L Hood
Journal: J Exp Med Date: 1985-11-01 Impact factor: 14.307

3. Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.

Authors: M Kronenberg; J Goverman; R Haars; M Malissen; E Kraig; L Phillips; T Delovitch; N Suciu-Foca; L Hood
Journal: Nature Date: 1985 Feb 21-27 Impact factor: 49.962

4. Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements.

Authors: M Malissen; C McCoy; D Blanc; J Trucy; C Devaux; A M Schmitt-Verhulst; F Fitch; L Hood; B Malissen
Journal: Nature Date: 1986 Jan 2-8 Impact factor: 49.962

5. T-cell receptor beta-chain expression: dependence on relatively few variable region genes.

Authors: M A Behlke; D G Spinella; H S Chou; W Sha; D L Hartl; D Y Loh
Journal: Science Date: 1985-08-09 Impact factor: 47.728

6. Localization of a T-cell receptor diversity-region element.

Authors: J Kavaler; M M Davis; Y Chien
Journal: Nature Date: 1984 Aug 2-8 Impact factor: 49.962

7. The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.

Authors: R K Barth; B S Kim; N C Lan; T Hunkapiller; N Sobieck; A Winoto; H Gershenfeld; C Okada; D Hansburg; I L Weissman
Journal: Nature Date: 1985 Aug 8-14 Impact factor: 49.962

8. Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.

Authors: C C Morton; A D Duby; R L Eddy; T B Shows; J G Seidman
Journal: Science Date: 1985-05-03 Impact factor: 47.728

9. The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14.

Authors: Z Dembić; W Bannwarth; B A Taylor; M Steinmetz
Journal: Nature Date: 1985 Mar 21-27 Impact factor: 49.962

10. Murine T cell receptor beta chain is encoded on chromosome 6.

Authors: N E Lee; P D'Eustachio; D Pravtcheva; F H Ruddle; S M Hedrick; M M Davis
Journal: J Exp Med Date: 1984-09-01 Impact factor: 14.307

17 in total

Review 1. Mouse chromosome 6.

Authors: R W Elliott; K J Moore
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. Identification of a mouse T-cell antigen receptor alpha-chain polymorphism by a V alpha 3.2 chain-specific monoclonal antibody.

Authors: Y Utsunomiya; J Bill; E Palmer; O Kanagawa
Journal: Immunogenetics Date: 1991 Impact factor: 2.846

Genomic organization of the mouse T-cell receptor beta-chain gene family.

1. Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction.

2. Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.

3. Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.

4. Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements.

5. T-cell receptor beta-chain expression: dependence on relatively few variable region genes.

6. Localization of a T-cell receptor diversity-region element.

7. The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.

8. Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.

9. The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14.

10. Murine T cell receptor beta chain is encoded on chromosome 6.

Review 1. Mouse chromosome 6.

2. Identification of a mouse T-cell antigen receptor alpha-chain polymorphism by a V alpha 3.2 chain-specific monoclonal antibody.

3. Biological transfer of the CBA Tcra locus into C57BL/6 mice.

4. T-cell receptor alpha-chain variable-region haplotypes of normal and autoimmune laboratory mouse strains.

Review 5. B and T cell antigen receptor repertoires in lupus/arthritis murine models.

6. Sequence of the V beta 13 gene used by an influenza-specific T cell.

7. Replication program of active and inactive multigene families in mammalian cells.

Review 8. T-cell receptor and autoimmune disease.

9. Organization of the T-cell antigen-receptor beta-chain locus in mice.

10. Analysis of V beta 17a expression in new mouse strains bearing the V beta a haplotype.