Literature DB >> 2412120

The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.

R K Barth, B S Kim, N C Lan, T Hunkapiller, N Sobieck, A Winoto, H Gershenfeld, C Okada, D Hansburg, I L Weissman.   

Abstract

Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller than that of immunoglobulin heavy-chain or light-chain genes. We suggest that beta-chain somatic diversification is concentrated at the V beta-D beta-J beta junctions.

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Year:  1985        PMID： 2412120     DOI： 10.1038/316517a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  109 in total

1.  Restricted heterogeneity in T-cell antigen receptor V beta gene usage in the lymph nodes and arthritic joints of mice.

Authors:  T M Haqqi; G D Anderson; S Banerjee; C S David
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

Review 2.  Evolutionary consequences of nonrandom damage and repair of chromatin domains.

Authors:  T Boulikas
Journal:  J Mol Evol       Date:  1992-08       Impact factor: 2.395

3.  Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity.

Authors:  R Jores; P M Alzari; T Meo
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

4.  Sequence of the TCR beta chain gene used by a T cell clone specific for the synthetic polymer, GAT.

Authors:  E Kraig; C C Kannapell; K A Zborowski; C W Pierce; J A Kapp
Journal:  Nucleic Acids Res       Date:  1990-10-11       Impact factor: 16.971

5.  Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes.

Authors:  C L Kuo; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

6.  Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.

Authors:  Markus Cornberg; Alex T Chen; Lee A Wilkinson; Michael A Brehm; Sung-Kwon Kim; Claudia Calcagno; Dario Ghersi; Roberto Puzone; Franco Celada; Raymond M Welsh; Liisa K Selin
Journal:  J Clin Invest       Date:  2006-04-13       Impact factor: 14.808

7.  The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides.

Authors:  J S Danska; A M Livingstone; V Paragas; T Ishihara; C G Fathman
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307

8.  Sequence and diversity of bovine T-cell receptor beta-chain genes.

Authors:  A Tanaka; N Ishiguro; M Shinagawa
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

9.  Profound alteration in an alpha beta T-cell antigen receptor repertoire due to polymorphism in the first complementarity-determining region of the beta chain.

Authors:  S J Gahm; B J Fowlkes; S C Jameson; N R Gascoigne; M M Cotterman; O Kanagawa; R H Schwartz; L A Matis
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

10.  Immunoregulatory activity of the T-cell receptor alpha chain demonstrated by retroviral gene transfer.

Authors:  D R Green; R Bissonnette; H G Zheng; T Onda; F Echeverri; R J Mogil; J K Steele; M Voralia; A Fotedar
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205
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