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Literature DB >> 2580639

Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction.

J Goverman, K Minard, N Shastri, T Hunkapiller, D Hansburg, E Sercarz, L Hood.

Abstract

The helper T cell clone 3H.25 is specific for hen egg white lysozyme and the class II MHC molecule I-Ab. This TH cell has three rearrangements in the beta-chain gene family-a V beta-D beta-J beta 1 and a D beta 2-J beta 2 rearrangement on one homolog and a D beta 1-J beta 2 rearrangement on the other. These observations demonstrate that this functional T lymphocyte expresses only a single V beta gene segment and, accordingly, exhibits allelic exclusion of beta-chain gene expression. The rearranged 3H.25 V beta gene segment is the same as that expressed in a T helper cell specific for cytochrome c and an I-Ek MHC molecule. Thus, there is no simple correlation between the V beta gene segment and antigen specificity or MHC restriction.

Entities: Gene

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Year: 1985 PMID： 2580639 DOI： 10.1016/0092-8674(85)90345-9

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

51 in total

1. Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes.

Authors: C L Kuo; L Hood
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

2. Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.

Authors: D H Sherman; P S Hochman; R Dick; R Tizard; K L Ramachandran; R A Flavell; B T Huber
Journal: Mol Cell Biol Date: 1987-05 Impact factor: 4.272

3. Productive re-arrangement at both alleles of the T-cell receptor beta-chain locus in CD4 T-cell clones specific for influenza haemagglutinin.

Authors: C A Smith; C M Graham; D B Thomas
Journal: Immunology Date: 1994-04 Impact factor: 7.397

4. T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity.

Authors: M S Horwitz; Y Yanagi; M B Oldstone
Journal: J Virol Date: 1994-01 Impact factor: 5.103

Review 5. T-cell clones and T-cell receptors.

Authors: F W Fitch
Journal: Microbiol Rev Date: 1986-03

10. Molecular analysis of the helper T cell response in murine interstitial nephritis. T cells recognizing an immunodominant epitope use multiple T cell receptor V beta genes with similarities across CDR3.

Authors: P S Heeger; W E Smoyer; T Saad; S Albert; C J Kelly; E G Neilson
Journal: J Clin Invest Date: 1994-11 Impact factor: 14.808

Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction.

1. Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes.

2. Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.

3. Productive re-arrangement at both alleles of the T-cell receptor beta-chain locus in CD4 T-cell clones specific for influenza haemagglutinin.

4. T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity.

Review 5. T-cell clones and T-cell receptors.

Review 6. T lymphocytes in synovia of patients with rheumatoid arthritis.

7. Initiator role of double stranded DNA in terminal transferase catalyzed polymerization reactions.

8. Clonal diversity of myelin basic protein-specific T lymphocytes.

9. An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice.

10. Molecular analysis of the helper T cell response in murine interstitial nephritis. T cells recognizing an immunodominant epitope use multiple T cell receptor V beta genes with similarities across CDR3.