| Literature DB >> 2523951 |
J W Kappler1, E Kushnir, P Marrack.
Abstract
A set of new mouse strains were produced that carry the V beta a haplotype of the TCR-alpha/beta and any of a number of different H-2 haplotypes on backgrounds derived from related C57BL, C57L, and C57BR mice. Study of V beta 17a expression in these mice confirms the association between the presence of IE and the deletion of V beta 17a+ T cells. A second H-2 gene causing deletion of V beta 17a+ T cells was mapped in these mice to the K end of H-2k, and H-2 influences on the level of selection of CD4+ V beta 17a+ T cells were indicated.Entities:
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Year: 1989 PMID: 2523951 PMCID: PMC2189295 DOI: 10.1084/jem.169.5.1533
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307