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Literature DB >> 30340032

Carbotoxicity-Noxious Effects of Carbohydrates.

Guido Kroemer¹, Carlos López-Otín², Frank Madeo³, Rafael de Cabo⁴.

Abstract

Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as "carbotoxicity." Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as well as the beneficial effects of reducing carbs in the diet. We discuss the molecular, cellular, and neuroendocrine mechanisms that link exaggerated carbohydrate intake to disease and accelerated aging as we outline dietary and pharmacologic strategies to combat carbotoxicity. Published by Elsevier Inc.

Entities: CellLine Chemical Disease Gene Species

Keywords: aging; diabetes; diet; health; longevity; metabolism; nutrition; obesity; restriction; sugar

Mesh：

Substances：
Dietary Carbohydrates

Year: 2018 PMID： 30340032 PMCID： PMC6265656 DOI： 10.1016/j.cell.2018.07.044

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

96 in total

Review 1. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.

Authors: Jung Sub Lim; Michele Mietus-Snyder; Annie Valente; Jean-Marc Schwarz; Robert H Lustig
Journal: Nat Rev Gastroenterol Hepatol Date: 2010-04-06 Impact factor: 46.802

Review 2. Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis.

Authors: Emma Sainsbury; Nathalie V Kizirian; Stephanie R Partridge; Timothy Gill; Stephen Colagiuri; Alice A Gibson
Journal: Diabetes Res Clin Pract Date: 2018-03-06 Impact factor: 5.602

3. wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.

Authors: Joshua P Gnerer; Robert A Kreber; Barry Ganetzky
Journal: Proc Natl Acad Sci U S A Date: 2006-09-28 Impact factor: 11.205

Review 4. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

Authors: Richard J Johnson; Mark S Segal; Yuri Sautin; Takahiko Nakagawa; Daniel I Feig; Duk-Hee Kang; Michael S Gersch; Steven Benner; Laura G Sánchez-Lozada
Journal: Am J Clin Nutr Date: 2007-10 Impact factor: 7.045

5. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women.

Authors: Yang Hu; Karen H Costenbader; Xiang Gao; May Al-Daabil; Jeffrey A Sparks; Daniel H Solomon; Frank B Hu; Elizabeth W Karlson; Bing Lu
Journal: Am J Clin Nutr Date: 2014-07-16 Impact factor: 7.045

6. Added sugar intake and cardiovascular diseases mortality among US adults.

Authors: Quanhe Yang; Zefeng Zhang; Edward W Gregg; W Dana Flanders; Robert Merritt; Frank B Hu
Journal: JAMA Intern Med Date: 2014-04 Impact factor: 21.873

Review 7. Fructose metabolism and metabolic disease.

Authors: Sarah A Hannou; Danielle E Haslam; Nicola M McKeown; Mark A Herman
Journal: J Clin Invest Date: 2018-02-01 Impact factor: 14.808

8. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.

Authors: Miguel A Lanaspa; Takuji Ishimoto; Nanxing Li; Christina Cicerchi; David J Orlicky; Philip Ruzycki; Philip Ruzicky; Christopher Rivard; Shinichiro Inaba; Carlos A Roncal-Jimenez; Elise S Bales; Christine P Diggle; Aruna Asipu; J Mark Petrash; Tomoki Kosugi; Shoichi Maruyama; Laura G Sanchez-Lozada; James L McManaman; David T Bonthron; Yuri Y Sautin; Richard J Johnson
Journal: Nat Commun Date: 2013 Impact factor: 14.919

9. Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.

Authors: Pavlos Missios; Yuan Zhou; Luis Miguel Guachalla; Guido von Figura; Andre Wegner; Sundaram Reddy Chakkarappan; Tina Binz; Anne Gompf; Götz Hartleben; Martin D Burkhalter; Veronika Wulff; Cagatay Günes; Rui Wang Sattler; Zhangfa Song; Thomas Illig; Susanne Klaus; Bernhard O Böhm; Tina Wenz; Karsten Hiller; K Lenhard Rudolph
Journal: Nat Commun Date: 2014-09-18 Impact factor: 14.919

10. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice.

Authors: Ana Andres-Hernando; Nanxing Li; Christina Cicerchi; Shinichiro Inaba; Wei Chen; Carlos Roncal-Jimenez; Myphuong T Le; Michael F Wempe; Tamara Milagres; Takuji Ishimoto; Mehdi Fini; Takahiko Nakagawa; Richard J Johnson; Miguel A Lanaspa
Journal: Nat Commun Date: 2017-02-13 Impact factor: 14.919

34 in total

1. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health.

Authors: Jibran A Wali; Annabelle J Milner; Alison W S Luk; Tamara J Pulpitel; Tim Dodgson; Harrison J W Facey; Devin Wahl; Melkam A Kebede; Alistair M Senior; Mitchell A Sullivan; Amanda E Brandon; Belinda Yau; Glen P Lockwood; Yen Chin Koay; Rosilene Ribeiro; Samantha M Solon-Biet; Kim S Bell-Anderson; John F O'Sullivan; Laurence Macia; Josephine M Forbes; Gregory J Cooney; Victoria C Cogger; Andrew Holmes; David Raubenheimer; David G Le Couteur; Stephen J Simpson
Journal: Nat Metab Date: 2021-06-08

Carbotoxicity-Noxious Effects of Carbohydrates.

Review 1. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.

Review 2. Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis.

3. wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.

Review 4. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

5. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women.

6. Added sugar intake and cardiovascular diseases mortality among US adults.

Review 7. Fructose metabolism and metabolic disease.

8. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.

9. Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.

10. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice.

1. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health.

Review 2. Drugging cancer metabolism: Expectations vs. reality.

Review 3. Targeting the gut and tumor microbiota in cancer.

Review 4. Intergenerational Metabolic Syndrome and Neuronal Network Hyperexcitability in Autism.

5. Perinatal diet influences health and survival in a mouse model of leukemia.

6. Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis.

Review 7. Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.

8. Ketosis versus carbotoxicity - metabolism determines the outcome of cancer immunotherapy.

Review 9. Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction.

10. Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis.