Literature DB >> 33553614

Ketosis versus carbotoxicity - metabolism determines the outcome of cancer immunotherapy.

Aitziber Buqué1, Lorenzo Galluzzi1,2,3,4,5, Guido Kroemer6,7,8,9,10.   

Abstract

Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  3-hydroxybutyrate; CTLA4; PD-1; immune checkpoint inhibitors; ketogenic diet; sucrose

Year:  2021        PMID： 33553614      PMCID： PMC7849725          DOI： 10.1080/23723556.2020.1868266

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The hallmarks of successful anticancer immunotherapy.

Authors:  Lorenzo Galluzzi; Timothy A Chan; Guido Kroemer; Jedd D Wolchok; Alejandro López-Soto
Journal:  Sci Transl Med       Date:  2018-09-19       Impact factor: 17.956

2.  Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

Authors:  Federico Pietrocola; Jonathan Pol; Erika Vacchelli; Shuan Rao; David P Enot; Elisa E Baracco; Sarah Levesque; Francesca Castoldi; Nicolas Jacquelot; Takahiro Yamazaki; Laura Senovilla; Guillermo Marino; Fernando Aranda; Sylvère Durand; Valentina Sica; Alexis Chery; Sylvie Lachkar; Verena Sigl; Norma Bloy; Aitziber Buque; Simonetta Falzoni; Bernhard Ryffel; Lionel Apetoh; Francesco Di Virgilio; Frank Madeo; Maria Chiara Maiuri; Laurence Zitvogel; Beth Levine; Josef M Penninger; Guido Kroemer
Journal:  Cancer Cell       Date:  2016-07-11       Impact factor: 31.743

3.  Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.

Authors:  Slaven Stekovic; Sebastian J Hofer; Norbert Tripolt; Miguel A Aon; Philipp Royer; Lukas Pein; Julia T Stadler; Tobias Pendl; Barbara Prietl; Jasmin Url; Sabrina Schroeder; Jelena Tadic; Tobias Eisenberg; Christoph Magnes; Michael Stumpe; Elmar Zuegner; Natalie Bordag; Regina Riedl; Albrecht Schmidt; Ewald Kolesnik; Nicolas Verheyen; Anna Springer; Tobias Madl; Frank Sinner; Rafael de Cabo; Guido Kroemer; Barbara Obermayer-Pietsch; Jörn Dengjel; Harald Sourij; Thomas R Pieber; Frank Madeo
Journal:  Cell Metab       Date:  2019-08-27       Impact factor: 27.287

4.  A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.

Authors:  Megan N Roberts; Marita A Wallace; Alexey A Tomilov; Zeyu Zhou; George R Marcotte; Dianna Tran; Gabriella Perez; Elena Gutierrez-Casado; Shinichiro Koike; Trina A Knotts; Denise M Imai; Stephen M Griffey; Kyoungmi Kim; Kevork Hagopian; Marissa Z McMackin; Fawaz G Haj; Keith Baar; Gino A Cortopassi; Jon J Ramsey; Jose Alberto Lopez-Dominguez
Journal:  Cell Metab       Date:  2017-09-05       Impact factor: 27.287

5.  Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

Authors:  John C Newman; Anthony J Covarrubias; Minghao Zhao; Xinxing Yu; Philipp Gut; Che-Ping Ng; Yu Huang; Saptarsi Haldar; Eric Verdin
Journal:  Cell Metab       Date:  2017-09-05       Impact factor: 27.287

6.  Metabolic effects of fasting on human and mouse blood in vivo.

Authors:  Federico Pietrocola; Yohann Demont; Francesca Castoldi; David Enot; Sylvère Durand; Michaela Semeraro; Elisa Elena Baracco; Jonathan Pol; Jose Manuel Bravo-San Pedro; Chloé Bordenave; Sarah Levesque; Juliette Humeau; Alexis Chery; Didier Métivier; Frank Madeo; M Chiara Maiuri; Guido Kroemer
Journal:  Autophagy       Date:  2017-01-06       Impact factor: 16.016

Review 7.  Carbotoxicity-Noxious Effects of Carbohydrates.

Authors:  Guido Kroemer; Carlos López-Otín; Frank Madeo; Rafael de Cabo
Journal:  Cell       Date:  2018-10-18       Impact factor: 41.582

8.  Dietary Carbohydrates Impair Healthspan and Promote Mortality.

Authors:  Meenakshi Ravichandran; Gerald Grandl; Michael Ristow
Journal:  Cell Metab       Date:  2017-10-03       Impact factor: 27.287

9.  A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

Authors:  Sarah Lévesque; Julie Le Naour; Federico Pietrocola; Juliette Paillet; Margerie Kremer; Francesca Castoldi; Elisa E Baracco; Yan Wang; Erika Vacchelli; Gautier Stoll; Ariane Jolly; Pierre De La Grange; Laurence Zitvogel; Guido Kroemer; Jonathan G Pol
Journal:  Oncoimmunology       Date:  2019-09-07       Impact factor: 8.110

10.  Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.

Authors:  Gladys Ferrere; Maryam Tidjani Alou; Peng Liu; Anne-Gaëlle Goubet; Marine Fidelle; Oliver Kepp; Sylvère Durand; Valerio Iebba; Aurélie Fluckiger; Romain Daillère; Cassandra Thelemaque; Claudia Grajeda-Iglesias; Carolina Alves Costa Silva; Fanny Aprahamian; Déborah Lefevre; Liwei Zhao; Bernhard Ryffel; Emeline Colomba; Monica Arnedos; Damien Drubay; Conrad Rauber; Didier Raoult; Francesco Asnicar; Tim Spector; Nicola Segata; Lisa Derosa; Guido Kroemer; Laurence Zitvogel
Journal:  JCI Insight       Date:  2021-01-25
  10 in total

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