| Literature DB >> 34099926 |
Jibran A Wali1,2,3, Annabelle J Milner4, Alison W S Luk4,5, Tamara J Pulpitel4,5, Tim Dodgson4,5, Harrison J W Facey4, Devin Wahl4,6, Melkam A Kebede4,5, Alistair M Senior4, Mitchell A Sullivan7, Amanda E Brandon4,8, Belinda Yau4,5, Glen P Lockwood6, Yen Chin Koay4,9, Rosilene Ribeiro4,5, Samantha M Solon-Biet4, Kim S Bell-Anderson4,5, John F O'Sullivan4,9,10, Laurence Macia4,8, Josephine M Forbes7, Gregory J Cooney4,8, Victoria C Cogger4,6, Andrew Holmes4,5, David Raubenheimer4,5, David G Le Couteur4,6, Stephen J Simpson11,12.
Abstract
Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in animal models. However, with transition to industrialised food systems, reduced dietary protein is associated with poor health outcomes in humans. Here we systematically interrogate the impact of carbohydrate quality in diets with varying carbohydrate and protein content. Studying 700 male mice on 33 isocaloric diets, we find that the type of carbohydrate and its digestibility profoundly shape the behavioural and physiological responses to protein dilution, modulate nutrient processing in the liver and alter the gut microbiota. Low (10%)-protein, high (70%)-carbohydrate diets promote the healthiest metabolic outcomes when carbohydrate comprises resistant starch (RS), yet the worst outcomes were with a 50:50 mixture of monosaccharides fructose and glucose. Our findings could explain the disparity between healthy, high-carbohydrate diets and the obesogenic impact of protein dilution by glucose-fructose mixtures associated with highly processed diets.Entities:
Year: 2021 PMID： 34099926 DOI： 10.1038/s42255-021-00393-9
Source DB: PubMed Journal: Nat Metab ISSN： 2522-5812