Colleen K McIlvennan1, Daniel D Matlock2, Jocelyn S Thompson3, Shannon M Dunlay4, Laura Blue5, Shane J LaRue6, Eldrin F Lewis7, Chetan B Patel5, Diane L Fairclough8, Erin C Leister8, Keith M Swetz9, Vicie Baldridge10, Mary Norine Walsh11, Larry A Allen3. 1. Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: colleen.mcilvennan@ucdenver.edu. 2. Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine, Aurora, Colorado; Veteran Affairs Eastern Colorado Geriatric Research Education and Clinical Center, Denver, Colorado. 3. Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine, Aurora, Colorado. 4. Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota. 5. Duke University Medical Center, Durham, North Carolina. 6. Washington University School of Medicine, St. Louis, Missouri. 7. Brigham and Women's Hospital, Boston, Massachusetts. 8. Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine, Aurora, Colorado; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado. 9. University of Alabama School of Medicine, Birmingham, Alabama. 10. Caregiver representative, Aurora, Colorado. 11. St. Vincent Heart Center, Division of Cardiology, Indianapolis, Indiana.
Abstract
OBJECTIVES: This study aims to characterize caregivers of patients considering destination therapy left ventricular assist device (DT-LVAD) and evaluate the effectiveness of a shared decision-making (SDM) intervention. BACKGROUND: Caregivers play an integral role in the care of patients with chronic illness. At the extreme, pursuing a DT-LVAD is a major preference-sensitive decision that requires high-level caregiver engagement. Yet, little is known about caregivers of patients considering DT-LVAD, and there is a paucity of research on the involvement of caregivers in medical decision-making. METHODS: A 6-center, stepped-wedge trial was conducted. After varying time in usual care (control), sites were transitioned to an SDM intervention consisting of staff education and pamphlet and video decision aids (DAs). The primary outcome was decision quality, measured by knowledge and values-choice concordance. RESULTS:From 2015 to 2017, 182 caregivers of patients considering DT-LVAD were enrolled (control group, n = 111; intervention group, n = 71). The median age was 61 years, 86.5% were female, and 75.8% were spouses. Caregiver knowledge (0% to 100%) improved from baseline to post-education in both groups: in the control group it improved from 64.2% to 73.3%; in the intervention group it improved from 62.6% to 76.4% (adjusted difference of difference: 4.8%; p = 0.08). At 1 month, correlation between stated values and caregiver-reported treatment choice was stronger in the intervention group (difference in Kendall's tau: 0.36, 95% confidence interval: 0.04 to 0.71; p = 0.03). Caregivers reported decisional conflict (0 to 100) at baseline (control group: 19.0 ± 2.1; intervention group: 21.4 ± 2.6), which decreased post-education more in the control group (control group: 9.0 ± 1.9, intervention group: 18.8 ± 2.4; p = 0.009). Caregivers in the control group were more likely to "definitely recommend" the educational materials than those in the intervention group (93.5% vs. 74.5%, respectively; p = 0.004). CONCLUSIONS: An SDM intervention improved concordance between caregiver values and treatment choice for their loved ones but did not significantly impact knowledge. Caregivers found the DAs less acceptable than more biased educational materials and exposure to DAs led to higher conflict initially. These findings highlight the complexity of SDM involving caregivers of patients with chronic illness. (PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device [DECIDE-LVAD]; NCT02344576).
RCT Entities:
OBJECTIVES: This study aims to characterize caregivers of patients considering destination therapy left ventricular assist device (DT-LVAD) and evaluate the effectiveness of a shared decision-making (SDM) intervention. BACKGROUND: Caregivers play an integral role in the care of patients with chronic illness. At the extreme, pursuing a DT-LVAD is a major preference-sensitive decision that requires high-level caregiver engagement. Yet, little is known about caregivers of patients considering DT-LVAD, and there is a paucity of research on the involvement of caregivers in medical decision-making. METHODS: A 6-center, stepped-wedge trial was conducted. After varying time in usual care (control), sites were transitioned to an SDM intervention consisting of staff education and pamphlet and video decision aids (DAs). The primary outcome was decision quality, measured by knowledge and values-choice concordance. RESULTS: From 2015 to 2017, 182 caregivers of patients considering DT-LVAD were enrolled (control group, n = 111; intervention group, n = 71). The median age was 61 years, 86.5% were female, and 75.8% were spouses. Caregiver knowledge (0% to 100%) improved from baseline to post-education in both groups: in the control group it improved from 64.2% to 73.3%; in the intervention group it improved from 62.6% to 76.4% (adjusted difference of difference: 4.8%; p = 0.08). At 1 month, correlation between stated values and caregiver-reported treatment choice was stronger in the intervention group (difference in Kendall's tau: 0.36, 95% confidence interval: 0.04 to 0.71; p = 0.03). Caregivers reported decisional conflict (0 to 100) at baseline (control group: 19.0 ± 2.1; intervention group: 21.4 ± 2.6), which decreased post-education more in the control group (control group: 9.0 ± 1.9, intervention group: 18.8 ± 2.4; p = 0.009). Caregivers in the control group were more likely to "definitely recommend" the educational materials than those in the intervention group (93.5% vs. 74.5%, respectively; p = 0.004). CONCLUSIONS: An SDM intervention improved concordance between caregiver values and treatment choice for their loved ones but did not significantly impact knowledge. Caregivers found the DAs less acceptable than more biased educational materials and exposure to DAs led to higher conflict initially. These findings highlight the complexity of SDM involving caregivers of patients with chronic illness. (PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device [DECIDE-LVAD]; NCT02344576).
Authors: Daniel D Matlock; Colleen K McIlvennan; Jocelyn S Thompson; Megan A Morris; Grace Venechuk; Shannon M Dunlay; Shane J LaRue; Eldrin F Lewis; Chetan B Patel; Laura Blue; Erin L Chaussee; Russell E Glasgow; Mary Norine Walsh; Larry A Allen Journal: Med Decis Making Date: 2020-04 Impact factor: 2.583
Authors: Megan M Streur; Jonathan P Auld; Ana Carolina Sauer Liberato; Jennifer A Beckman; Claudius Mahr; Elaine A Thompson; Cynthia M Dougherty Journal: J Card Fail Date: 2020-06-05 Impact factor: 5.712
Authors: Colleen K McIlvennan; Jacqueline Jones; Marybeth Makic; Paula M Meek; Erin Chaussee; Jocelyn S Thompson; Daniel D Matlock; Larry A Allen Journal: Circ Heart Fail Date: 2021-09-01 Impact factor: 10.447
Authors: Janet Jull; Sascha Köpke; Maureen Smith; Meg Carley; Jeanette Finderup; Anne C Rahn; Laura Boland; Sandra Dunn; Andrew A Dwyer; Jürgen Kasper; Simone Maria Kienlin; France Légaré; Krystina B Lewis; Anne Lyddiatt; Claudia Rutherford; Junqiang Zhao; Tamara Rader; Ian D Graham; Dawn Stacey Journal: Cochrane Database Syst Rev Date: 2021-11-08
Authors: Colleen K McIlvennan; Daniel D Matlock; Larry A Allen; Jocelyn S Thompson; Krista W Ranby; Timothy S Sannes Journal: Circ Cardiovasc Qual Outcomes Date: 2020-03-09
Authors: Jocelyn S Thompson; Monica D Fitzgerald; Larry A Allen; Colleen K McIlvennan; Russell E Glasgow; Matthew Wynia; Megan A Morris; John Beilenson; Chris Gherst; Dan D Matlock Journal: Circ Cardiovasc Qual Outcomes Date: 2021-02-03
Authors: Jorie M Butler; Bryan Gibson; Olga V Patterson; Laura J Damschroder; Corrinne H Halls; Daniel W Denhalter; Matthew H Samore; Haojia Li; Yue Zhang; Scott L DuVall Journal: BMC Med Inform Decis Mak Date: 2022-03-12 Impact factor: 2.796