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Literature DB >> 3022009

Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.

Abstract

Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.

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Year: 1986 PMID： 3022009 PMCID： PMC288954

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

10 in total

1. Small and middle T antigens contribute to lytic and abortive polyomavirus infection.

Authors: H Türler; C Salomon
Journal: J Virol Date: 1985-02 Impact factor: 5.103

2. Homologous recombination of polyoma virus DNA in mouse cells.

Authors: H Kovar; E Wintersberger
Journal: Mol Gen Genet Date: 1985

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Authors: D Templeton; S Simon; W Eckhart
Journal: J Virol Date: 1986-01 Impact factor: 5.103

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Authors: B Hirt
Journal: J Mol Biol Date: 1967-06-14 Impact factor: 5.469

5. The roles of individual polyoma virus early proteins in oncogenic transformation.

Authors: M Rassoulzadegan; A Cowie; A Carr; N Glaichenhaus; R Kamen; F Cuzin
Journal: Nature Date: 1982-12-23 Impact factor: 49.962

6. Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells.

Authors: M Ellman; I Bikel; J Figge; T Roberts; R Schlossman; D M Livingston
Journal: J Virol Date: 1984-05 Impact factor: 5.103

7. Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.

Authors: M Rassoulzadegan; Z Naghashfar; A Cowie; A Carr; M Grisoni; R Kamen; F Cuzin
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

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Authors: Z Y Zhu; G M Veldman; A Cowie; A Carr; B Schaffhausen; R Kamen
Journal: J Virol Date: 1984-07 Impact factor: 5.103

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Authors: R Treisman; U Novak; J Favaloro; R Kamen
Journal: Nature Date: 1981-08-13 Impact factor: 49.962

10. T-antigen expression by polyoma mutants with modified RNA splicing.

Authors: S V Nilsson; G Magnusson
Journal: EMBO J Date: 1983 Impact factor: 11.598

10 in total

15 in total

1. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.

Authors: Shaida Andrabi; Justin H Hwang; Jennifer Kean Choe; Thomas M Roberts; Brian S Schaffhausen
Journal: J Virol Date: 2011-08-10 Impact factor: 5.103

2. Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.

Authors: H Li; K Söderbärg; H Houshmand; Z Y You; G Magnusson
Journal: J Virol Date: 2001-03 Impact factor: 5.103

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Authors: C J Norbury; M Fried
Journal: J Virol Date: 1987-12 Impact factor: 5.103

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Authors: Kerry A Whalen; Rowena de Jesus; Jennifer A Kean; Brian S Schaffhausen
Journal: J Virol Date: 2005-08 Impact factor: 5.103

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Authors: G M Glenn; W Eckhart
Journal: J Virol Date: 1990-05 Impact factor: 5.103

6. Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.

Authors: K P Mullane; M Ratnofsky; X Culleré; B Schaffhausen
Journal: Mol Cell Biol Date: 1998-12 Impact factor: 4.272

7. Optimal replication of plasmids carrying polyomavirus origin regions requires two high-affinity binding sites for large T antigen.

Authors: I Weichselbraun; G Haider; E Wintersberger
Journal: J Virol Date: 1989-02 Impact factor: 5.103

8. Mutational analysis of polyomavirus small-T-antigen functions in productive infection and in transformation.

Authors: I Martens; S A Nilsson; S Linder; G Magnusson
Journal: J Virol Date: 1989-05 Impact factor: 5.103

9. Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.

Authors: M Gassmann; G Donoho; P Berg
Journal: Proc Natl Acad Sci U S A Date: 1995-02-28 Impact factor: 11.205

10. Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.

Authors: G M Glenn; W Eckhart
Journal: J Virol Date: 1993-04 Impact factor: 5.103