Literature DB >> 3001358

Truncated forms of the polyomavirus middle T antigen can substitute for the small T antigen in lytic infection.

D Templeton, S Simon, W Eckhart.   

Abstract

Cloned polyomavirus genomes encoding the small T antigen or truncated forms of the middle T antigen facilitated the growth of genomes encoding only the large T antigen in mouse 3T6 cells. We conclude that an N-terminal domain of the middle T antigen, in the appropriate cellular location, can substitute for the small T antigen during lytic infection.

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Year:  1986        PMID： 3001358      PMCID： PMC252738     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  11 in total

1.  Analysis of host range of nontransforming polyoma virus mutants.

Authors:  E Goldman; T L Benjamin
Journal:  Virology       Date:  1975-08       Impact factor: 3.616

2.  Host range selection of transformation-defective hr-t mutants of polyoma virus.

Authors:  R J Staneloni; M M Fluck; T L Benjamin
Journal:  Virology       Date:  1977-04       Impact factor: 3.616

3.  Small and middle T antigens contribute to lytic and abortive polyomavirus infection.

Authors:  H Türler; C Salomon
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

4.  Host range mutants of polyoma virus.

Authors:  T L Benjamin
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

5.  A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation.

Authors:  T J Liang; G G Carmichael; T L Benjamin
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272

6.  Mutation causing premature termination of the polyoma virus medium T antigen blocks cell transformation.

Authors:  D Templeton; W Eckhart
Journal:  J Virol       Date:  1982-03       Impact factor: 5.103

7.  Characterization of viable mutants of polyomavirus cold sensitive for maintenance of cell transformation.

Authors:  D Templeton; W Eckhart
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

8.  N-terminal amino acid sequences of the polyoma middle-size T antigen are important for protein kinase activity and cell transformation.

Authors:  D Templeton; W Eckhart
Journal:  Mol Cell Biol       Date:  1984-05       Impact factor: 4.272

9.  Host range transforming gene of polyoma virus plays a role in virus assembly.

Authors:  R L Garcea; T L Benjamin
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

Review 10.  The hr-t gene of polyoma virus.

Authors:  T L Benjamin
Journal:  Biochim Biophys Acta       Date:  1982-12-21
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  14 in total

Review 1.  Natural biology of polyomavirus middle T antigen.

Authors:  K A Gottlieb; L P Villarreal
Journal:  Microbiol Mol Biol Rev       Date:  2001-06       Impact factor: 11.056

2.  Polyomavirus early region alternative poly(A) site: 3'-end heterogeneity and altered splicing pattern.

Authors:  C J Norbury; M Fried
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

3.  Genetic analysis of the polyomavirus DnaJ domain.

Authors:  Kerry A Whalen; Rowena de Jesus; Jennifer A Kean; Brian S Schaffhausen
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

4.  Transcriptional regulation of early-response genes during polyomavirus infection.

Authors:  G M Glenn; W Eckhart
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

5.  On the functional roles of simian virus 40 large and small T-antigen in the induction of a mitotic host response.

Authors:  J F Gauchat; R Weil
Journal:  Nucleic Acids Res       Date:  1986-12-09       Impact factor: 16.971

Review 6.  Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

Authors:  Michele M Fluck; Brian S Schaffhausen
Journal:  Microbiol Mol Biol Rev       Date:  2009-09       Impact factor: 11.056

7.  Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.

Authors:  K P Mullane; M Ratnofsky; X Culleré; B Schaffhausen
Journal:  Mol Cell Biol       Date:  1998-12       Impact factor: 4.272

8.  Mutational analysis of polyomavirus small-T-antigen functions in productive infection and in transformation.

Authors:  I Martens; S A Nilsson; S Linder; G Magnusson
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103

9.  Overproduction of polyomavirus middle T antigen in mammalian cells through the use of an adenovirus vector.

Authors:  D Davidson; J A Hassell
Journal:  J Virol       Date:  1987-04       Impact factor: 5.103

10.  Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.

Authors:  G M Glenn; W Eckhart
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103
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