Literature DB >> 30216070

A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids.

Nicolle A Doering1, Kevin G M Kou1, Krissada Norseeda1, Jack C Lee1, Christopher J Marth1, Gary M Gallego1, Richmond Sarpong1.   

Abstract

A copper-mediated conjugate addition of electron-rich aryl groups into a complex vinyl nitrile using arylmagnesium bromides is reported. The conjugate addition adducts were advanced toward the synthesis of designed aconitine-type analogues. The variation in oxygenation patterns on the arene coupling partner, introduced through the current conjugate addition approach, may ultimately provide insight into structure-activity relationships of the diterpenoid alkaloids.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 30216070      PMCID： PMC6214151          DOI： 10.1021/acs.joc.8b01967

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  19 in total

1.  NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities.

Authors:  Hugo E. Gottlieb; Vadim Kotlyar; Abraham Nudelman
Journal:  J Org Chem       Date:  1997-10-17       Impact factor: 4.354

Review 2.  C20-diterpenoid alkaloids.

Authors:  Feng-Peng Wang; Xiao-Tian Liang
Journal:  Alkaloids Chem Biol       Date:  2002

Review 3.  Diterpenoid alkaloids.

Authors:  Feng-Peng Wang; Qiao-Hong Chen; Xiao-Yu Liu
Journal:  Nat Prod Rep       Date:  2010-02-15       Impact factor: 13.423

4.  The C19-diterpenoid alkaloids.

Authors:  Feng-Peng Wang; Qiao-Hong Chen
Journal:  Alkaloids Chem Biol       Date:  2010

Review 5.  The C18-diterpenoid alkaloids.

Authors:  Feng-Peng Wang; Qiao-Hong Chen; Xiao-Tian Liang
Journal:  Alkaloids Chem Biol       Date:  2009

6.  Antiarrhythmic ionic mechanism of Guanfu base A--Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs.

Authors:  Si-Si Jin; Qiao Guo; Jing Xu; Peng Yu; Jing-Han Liu; Yi-Qun Tang
Journal:  Chin J Nat Med       Date:  2015-05

7.  Syntheses of Denudatine Diterpenoid Alkaloids: Cochlearenine, N-Ethyl-1α-hydroxy-17-veratroyldictyzine, and Paniculamine.

Authors:  Kevin G M Kou; Beryl X Li; Jack C Lee; Gary M Gallego; Terry P Lebold; Antonio G DiPasquale; Richmond Sarpong
Journal:  J Am Chem Soc       Date:  2016-08-22       Impact factor: 15.419

8.  Palladium(II) acetate mediated oxidative cyclization of omega-unsaturated alpha-cyano ketones. A facile methylenecyclopentane annulation process.

Authors:  Liang-Rern Kung; Che-Hao Tu; Kak-Shan Shia; Hsing-Jang Liu
Journal:  Chem Commun (Camb)       Date:  2003-10-07       Impact factor: 6.222

9.  Network-analysis-guided synthesis of weisaconitine D and liljestrandinine.

Authors:  C J Marth; G M Gallego; J C Lee; T P Lebold; S Kulyk; K G M Kou; J Qin; R Lilien; R Sarpong
Journal:  Nature       Date:  2015-12-24       Impact factor: 49.962

Review 10.  Ion channel pharmacology.

Authors:  Diana Conte Camerino; Domenico Tricarico; Jean-François Desaphy
Journal:  Neurotherapeutics       Date:  2007-04       Impact factor: 7.620
View more
  1 in total

1.  The 1α-hydroxy-A-rings of norditerpenoid alkaloids are twisted-boat conformers.

Authors:  Ziyu Zeng; Ashraf M A Qasem; Gabriele Kociok-Köhn; Michael G Rowan; Ian S Blagbrough
Journal:  RSC Adv       Date:  2020-05-18       Impact factor: 3.361
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.