The denudatine-type diterpenoid alkaloids cochlearenine, N-ethyl-1α-hydroxy-17-veratroyldictyzine, and paniculamine have been synthesized for the first time (25, 26, and 26 steps from 16, respectively). These syntheses take advantage of a common intermediate (8) that we have previously employed in preparing aconitine-type natural products. The syntheses reported herein complete the realization of a unified strategy for the preparation of C20, C19, and C18 diterpenoid alkaloids.
The denudatine-n class="Chemical">typediterpenoid alkaloidscochlearenine, N-ethyl-1α-hydroxy-17-veratroyldictyzine, and paniculamine have been synthesized for the first time (25, 26, and 26 steps from 16, respectively). These syntheses take advantage of a common intermediate (8) that we have previously employed in preparing aconitine-type natural products. The syntheses reported herein complete the realization of a unified strategy for the preparation of C20, C19, and C18diterpenoid alkaloids.
Authors: Nicolle A Doering; Kevin G M Kou; Krissada Norseeda; Jack C Lee; Christopher J Marth; Gary M Gallego; Richmond Sarpong Journal: J Org Chem Date: 2018-09-28 Impact factor: 4.354
Authors: Kevin G M Kou; Jason J Pflueger; Toshihiro Kiho; Louis C Morrill; Ethan L Fisher; Kyle Clagg; Terry P Lebold; Jessica K Kisunzu; Richmond Sarpong Journal: J Am Chem Soc Date: 2018-06-19 Impact factor: 15.419
Authors: Jason J Pflueger; Louis C Morrill; Justine N deGruyter; Melecio A Perea; Richmond Sarpong Journal: Org Lett Date: 2017-08-18 Impact factor: 6.005
Authors: Kevin G M Kou; Svitlana Kulyk; Christopher J Marth; Jack C Lee; Nicolle A Doering; Beryl X Li; Gary M Gallego; Terry P Lebold; Richmond Sarpong Journal: J Am Chem Soc Date: 2017-09-20 Impact factor: 15.419