| Literature DB >> 30152086 |
Andrea Merker1, Luitgard Neumeyer2, Niels Thomas Hertel3, Giedre Grigelioniene4,5,6, Klaus Mohnike7, Lars Hagenäs1,2.
Abstract
The aims of this study was to construct references for sitting height, leg length, arm span, relative sitting height (sitting height/height), and foot length and to discuss the development for these anthropometric variables in achondroplasia. Sex-specific references covering ±2 SD are presented for ages 2-20 years. Legs and arms in achondroplasia are already at 2 years of age considerably shorter than in the general population and this deviation increases with age. At adult ages, legs are almost 50% shorter than in the general population and arm span roughly 35% shorter. As sitting height is only mildly affected, relative sitting height position develops far beyond normal ranges. Foot length is also not as affected as limbs.Entities:
Keywords: GAMLSS; achondroplasia; arm span; body proportion; foot length; growth; leg length; relative sitting height; sitting height
Mesh:
Year: 2018 PMID: 30152086 DOI: 10.1002/ajmg.a.40356
Source DB: PubMed Journal: Am J Med Genet A ISSN: 1552-4825 Impact factor: 2.802