Anna J Swan1, Philip C Kendall2, Thomas Olino2, Golda Ginsburg3, Courtney Keeton4, Scott Compton5, John Piacentini6, Tara Peris6, Dara Sakolsky7, Boris Birmaher7, Anne Marie Albano8. 1. Department of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone. 2. Department of Psychology, Temple University. 3. Child Division of Department of Psychiatry, University of Connecticut Health. 4. Department of Psychiatry and Behavioral Services, Johns Hopkins University School of Medicine. 5. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center. 6. Division of Child and Adolescent Psychiatry, University of California, Los Angeles. 7. Department of Psychiatry, University of Pittsburgh. 8. Department of Psychiatry, Columbia University.
Abstract
OBJECTIVE: To report functional outcomes from the multisite Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), which examined the impact of youth anxiety treatment (cognitive-behavioral therapy [CBT], coping cat; Sertraline, SRT; COMB [CBT + SRT]; pill placebo) on (a) global and (b) domain-specific functioning assessed an average of 3.1 times, 3- to 12-years postrandomization (first assessment = mean 6.5 years postrandomization). METHOD: Three-hundred and 19 of 488 families from the Child/Adolescent Anxiety Multimodal Study (CAMS; Walkup et al., 2008) participated. Growth curve modeling examined the impact of treatment condition and acute treatment outcomes (i.e., response, remission) on global functioning, global and domain-specific impairment, and life satisfaction across follow-up visits. Logistic regressions explored the impact of treatment remission and condition on low frequency events (arrests/convictions) and education. RESULTS: Treatment responders and remitters demonstrated better global functioning, decreased overall impairment, and increased life satisfaction at follow-up. Treatment remission, but not response, predicted decreased domain-specific impairment (social relationships, self-care/independence, academic functioning), and maintenance of increased life satisfaction across follow-ups. Participants in the CBT condition, compared with pill placebo, demonstrated improved trajectories pertaining to life satisfaction, overall impairment, and impairment in academic functioning. Randomization to CBT or COMB treatment was associated with increasing employment rates. Trajectories for participants randomized to SRT was not significantly different from placebo. Treatment outcome and condition did not predict legal outcomes, school/work variables, or family life. CONCLUSION: Positive early intervention outcomes are associated with improved overall functioning, life satisfaction, and functioning within specific domains 6.5 years posttreatment. Treatment type differentially predicted trajectories of functioning. Findings support the positive impact of pediatric anxiety treatment into adolescence and early adulthood. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
RCT Entities:
OBJECTIVE: To report functional outcomes from the multisite Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), which examined the impact of youth anxiety treatment (cognitive-behavioral therapy [CBT], coping cat; Sertraline, SRT; COMB [CBT + SRT]; pill placebo) on (a) global and (b) domain-specific functioning assessed an average of 3.1 times, 3- to 12-years postrandomization (first assessment = mean 6.5 years postrandomization). METHOD: Three-hundred and 19 of 488 families from the Child/Adolescent Anxiety Multimodal Study (CAMS; Walkup et al., 2008) participated. Growth curve modeling examined the impact of treatment condition and acute treatment outcomes (i.e., response, remission) on global functioning, global and domain-specific impairment, and life satisfaction across follow-up visits. Logistic regressions explored the impact of treatment remission and condition on low frequency events (arrests/convictions) and education. RESULTS: Treatment responders and remitters demonstrated better global functioning, decreased overall impairment, and increased life satisfaction at follow-up. Treatment remission, but not response, predicted decreased domain-specific impairment (social relationships, self-care/independence, academic functioning), and maintenance of increased life satisfaction across follow-ups. Participants in the CBT condition, compared with pill placebo, demonstrated improved trajectories pertaining to life satisfaction, overall impairment, and impairment in academic functioning. Randomization to CBT or COMB treatment was associated with increasing employment rates. Trajectories for participants randomized to SRT was not significantly different from placebo. Treatment outcome and condition did not predict legal outcomes, school/work variables, or family life. CONCLUSION: Positive early intervention outcomes are associated with improved overall functioning, life satisfaction, and functioning within specific domains 6.5 years posttreatment. Treatment type differentially predicted trajectories of functioning. Findings support the positive impact of pediatric anxiety treatment into adolescence and early adulthood. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Authors: William E Copeland; Shari Miller-Johnson; Gordon Keeler; Adrian Angold; E Jane Costello Journal: Am J Psychiatry Date: 2007-11 Impact factor: 18.112
Authors: Scott N Compton; John T Walkup; Anne Marie Albano; John C Piacentini; Boris Birmaher; Joel T Sherrill; Golda S Ginsburg; Moira A Rynn; James T McCracken; Bruce D Waslick; Satish Iyengar; Phillip C Kendall; John S March Journal: Child Adolesc Psychiatry Ment Health Date: 2010-01-05 Impact factor: 3.033
Authors: Andrea B Temkin; Renae Beaumont; Katarzyna Wkya; Jo R Hariton; Barabra L Flye; Elisabeth Sheridan; Amy Miranda; Jamie Vela; Elaina Zendegui; Jennifer Schild; Shannon Gasparro; Daphne Loubriel; Andreas Damianides; Julia Weisman; Alexandra Silvestre; Mina Yadegar; Corinne Catarozoli; Shannon M Bennett Journal: Res Child Adolesc Psychopathol Date: 2022-04-20
Authors: Jeffrey J Wood; Philip C Kendall; Karen S Wood; Connor M Kerns; Michael Seltzer; Brent J Small; Adam B Lewin; Eric A Storch Journal: JAMA Psychiatry Date: 2020-05-01 Impact factor: 21.596
Authors: Elana R Kagan; Hannah E Frank; Lesley A Norris; Sophie A Palitz; Erika A Chiappini; Mark J Knepley; Margaret E Crane; Katherine E Phillips; Golda S Ginsburg; Courtney Keeton; Anne Marie Albano; John Piacentini; Tara Peris; Scott Compton; Dara Sakolsky; Boris Birmaher; Philip C Kendall Journal: Child Psychiatry Hum Dev Date: 2021-02
Authors: Margaret E Crane; Lesley A Norris; Hannah E Frank; Joshua Klugman; Golda S Ginsburg; Courtney Keeton; Anne Marie Albano; John Piacentini; Tara S Peris; Scott N Compton; Dara Sakolsky; Boris Birmaher; Philip C Kendall Journal: J Consult Clin Psychol Date: 2021-02