Literature DB >> 2892400

Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

G M Lathrop1, M Farrall, P O'Connell, B Wainwright, M Leppert, Y Nakamura, N Lench, H Kruyer, M Dean, M Park.   

Abstract

The genetic map in the region of human chromosome 7 that harbors the gene for cystic fibrosis (CF) has been refined by multilocus linkage studies in an expanded database including a large set of normal families. Six loci known to be linked to CF were examined: MET, an oncogene; COL1A2, collagen, TCRB, T-cell-receptor beta polypeptide; and three arbitrary loci--D7S8, D7S13, and D7S16--defined by probes pJ3.11, pB79a, and p7C22, respectively. The gene order with greatest statistical support is COL1A2-D7S13-D7S16-MET-D7S8-TCRB. Linkage analysis in families segregating for CF suggested that the most likely location of the CF gene on this map is between MET and D7S8.

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Year:  1988        PMID： 2892400      PMCID： PMC1715336     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  17 in total

1.  A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7.

Authors:  R G Knowlton; O Cohen-Haguenauer; N Van Cong; J Frézal; V A Brown; D Barker; J C Braman; J W Schumm; L C Tsui; M Buchwald
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

2.  Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis.

Authors:  P J Scambler; B J Wainwright; E Watson; G Bates; G Bell; R Williamson; M Farrall
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

3.  Linkage of DNA probe B79a (D7S13) to cystic fibrosis.

Authors:  B J Wainwright; L C Tsui; M Leppert; M Buchwald; X Estivill; P O'Connell; M Lathrop; J M Lalouel; R White; R Williamson
Journal:  Am J Hum Genet       Date:  1987-11       Impact factor: 11.025

4.  Linkage of COL1A2 collagen gene to cystic fibrosis, and its clinical implications.

Authors:  P J Scambler; B J Wainwright; M Farrall; J Bell; P Stanier; N J Lench; G Bell; H Kruyer; F Ramirez; R Williamson
Journal:  Lancet       Date:  1985-11-30       Impact factor: 79.321

5.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

6.  The human met oncogene is related to the tyrosine kinase oncogenes.

Authors:  M Dean; M Park; M M Le Beau; T S Robins; M O Diaz; J D Rowley; D G Blair; G F Vande Woude
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

7.  A closely linked genetic marker for cystic fibrosis.

Authors:  R White; S Woodward; M Leppert; P O'Connell; M Hoff; J Herbst; J M Lalouel; M Dean; G Vande Woude
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

8.  Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

Authors:  L C Tsui; M Buchwald; D Barker; J C Braman; R Knowlton; J W Schumm; H Eiberg; J Mohr; D Kennedy; N Plavsic
Journal:  Science       Date:  1985-11-29       Impact factor: 47.728

9.  Localization of cystic fibrosis locus to human chromosome 7cen-q22.

Authors:  B J Wainwright; P J Scambler; J Schmidtke; E A Watson; H Y Law; M Farrall; H J Cooke; H Eiberg; R Williamson
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

10.  Linkage relationships of paraoxonase (PON) with other markers: indication of PON-cystic fibrosis synteny.

Authors:  H Eiberg; J Mohr; K Schmiegelow; L S Nielsen; R Williamson
Journal:  Clin Genet       Date:  1985-10       Impact factor: 4.438
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  25 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Crossover in a Spanish cystic fibrosis family.

Authors:  E Fernández; M Villamar; J Benítez
Journal:  Hum Genet       Date:  1990-11       Impact factor: 4.132

Review 3.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

4.  Joint estimation of recombination fractions and interference coefficients in multilocus linkage analysis.

Authors:  L P Zhao; E Thompson; R Prentice
Journal:  Am J Hum Genet       Date:  1990-08       Impact factor: 11.025

5.  Analysis of the transgenome of MET transfectant cell lines reveals that MET activation is accompanied by an interstitial insertion.

Authors:  P J Scambler; B Wainwright; M Ramsay; M Farrall; G Bates; M F Ho; C Cooper
Journal:  Hum Genet       Date:  1990-02       Impact factor: 4.132

6.  Approaches to localizing disease genes as applied to cystic fibrosis.

Authors:  M Dean; M L Drumm; C Stewart; B Gerrard; A Perry; N Hidaka; J L Cole; F S Collins; M C Iannuzzi
Journal:  Nucleic Acids Res       Date:  1990-01-25       Impact factor: 16.971

7.  Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8.

Authors:  M Dean; J A Amos; J Lynch; G Romeo; M Devoto; K Ward; D Halley; B Oostra; M Ferrari; S Russo
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

8.  Studies of RFLP closely linked to the cystic fibrosis locus throughout Europe lead to new considerations in populations genetics.

Authors:  J L Serre; B Simon-Bouy; E Mornet; B Jaume-Roig; A Balassopoulou; M Schwartz; A Taillandier; J Boué; A Boué
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132

9.  Regional assignment of 41 human DNA fragments on chromosome 7 by means of a somatic cell hybrid panel.

Authors:  A Jobs; D Klein-Bölting; A S Jandel; A Driesel; K Olek; K H Grzeschik
Journal:  Hum Genet       Date:  1990-01       Impact factor: 4.132

10.  Cloning human telomeric DNA fragments into Saccharomyces cerevisiae using a yeast-artificial-chromosome vector.

Authors:  H C Riethman; R K Moyzis; J Meyne; D T Burke; M V Olson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205
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