Literature DB >> 3467587

Genetic analysis of cystic fibrosis using linked DNA markers.

L C Tsui, K Buetow, M Buchwald.   

Abstract

Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families. The analysis confirms the previous observations that both MET and D7S8 are closely linked to CF. Based on the result from one family, MET appears to be more proximal to the centromere than CF. Our analysis also suggests that genetic heterogeneity may account for the high recombination fraction between CF and D7S8 observed in another family. In addition, a strong linkage disequilibrium has been observed between CF and the two closely flanking markers.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3467587      PMCID： PMC1684123     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  22 in total

1.  Sequential tests for the detection of linkage.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1955-09       Impact factor: 11.025

2.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

3.  Report of the Committee on Methods of Linkage Analysis and Reporting.

Authors:  P M Conneally; J H Edwards; K K Kidd; J M Lalouel; N E Morton; J Ott; R White
Journal:  Cytogenet Cell Genet       Date:  1985

4.  Linkage analysis and family classification under heterogeneity.

Authors:  J Ott
Journal:  Ann Hum Genet       Date:  1983-10       Impact factor: 1.670

5.  Phenotypic heterogeneity in cystic fibrosis.

Authors:  C F Sing; D R Risser; W F Howatt; R P Erickson
Journal:  Am J Med Genet       Date:  1982-10

6.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

7.  Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta.

Authors:  P Tsipouras; A L Børresen; L A Dickson; K Berg; D J Prockop; F Ramirez
Journal:  Am J Hum Genet       Date:  1984-11       Impact factor: 11.025

8.  A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.

Authors:  Y Yanagi; Y Yoshikai; K Leggett; S P Clark; I Aleksander; T W Mak
Journal:  Nature       Date:  1984 Mar 8-14       Impact factor: 49.962

9.  Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

Authors:  L C Tsui; M Buchwald; D Barker; J C Braman; R Knowlton; J W Schumm; H Eiberg; J Mohr; D Kennedy; N Plavsic
Journal:  Science       Date:  1985-11-29       Impact factor: 47.728

10.  Linkage relationships of paraoxonase (PON) with other markers: indication of PON-cystic fibrosis synteny.

Authors:  H Eiberg; J Mohr; K Schmiegelow; L S Nielsen; R Williamson
Journal:  Clin Genet       Date:  1985-10       Impact factor: 4.438
View more
  11 in total

1.  Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population.

Authors:  Heather E Collins-Schramm; Bill Chima; Darwin J Operario; Lindsey A Criswell; Michael F Seldin
Journal:  Hum Genet       Date:  2003-06-03       Impact factor: 4.132

2.  Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.

Authors:  J M Rommens; S Zengerling; J Burns; G Melmer; B S Kerem; N Plavsic; M Zsiga; D Kennedy; D Markiewicz; R Rozmahel
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

3.  Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.

Authors:  G R Cutting; S E Antonarakis; K H Buetow; L M Kasch; B J Rosenstein; H H Kazazian
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

4.  Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

Authors:  A Beaudet; A Bowcock; M Buchwald; L Cavalli-Sforza; M Farrall; M C King; K Klinger; J M Lalouel; G Lathrop; S Naylor
Journal:  Am J Hum Genet       Date:  1986-12       Impact factor: 11.025

Review 5.  Genetic markers on chromosome 7.

Authors:  L C Tsui
Journal:  J Med Genet       Date:  1988-05       Impact factor: 6.318

6.  Cystic fibrosis.

Authors:  I Harwood; F Rosas; D K Edwards; J Kelso; W L Nyhan
Journal:  West J Med       Date:  1988-01

7.  Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

Authors:  G M Lathrop; M Farrall; P O'Connell; B Wainwright; M Leppert; Y Nakamura; N Lench; H Kruyer; M Dean; M Park
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

8.  Tracing the mutations in cystic fibrosis by means of closely linked DNA markers.

Authors:  L C Tsui
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

9.  DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis.

Authors:  B S Kerem; J A Buchanan; P Durie; M L Corey; H Levison; J M Rommens; M Buchwald; L C Tsui
Journal:  Am J Hum Genet       Date:  1989-06       Impact factor: 11.025

10.  Impact of gene patents and licensing practices on access to genetic testing for cystic fibrosis.

Authors:  Subhashini Chandrasekharan; Christopher Heaney; Tamara James; Chris Conover; Robert Cook-Deegan
Journal:  Genet Med       Date:  2010-04       Impact factor: 8.822
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.