CONtrast Conformed Electrical Properties Tomography (CONCEPT) Based on Multi- Channel Transmission and Alternating Direction Method of Multipliers.

In magnetic resonance-based electrical properties tomography (EPT), circularly polarized magnetic field B1 from a transmit radiofrequency (RF) coil is measured and utilized to infer the electrical conductivity and permittivity of biological tissues. Compared with a quadrature RF coil, a multi-channel transmit coil provides a plurality of unique transmit B1 patterns that help to alleviate the under-determinedness of EPT reconstruction problem, and it also allows to circumvent the "transceive phase assumption" that fails at ultra-high-field MRI. Here, a new approach, contrast conformed electrical properties tomography or CONCEPT, is proposed based on the multi-channel transmission that retrieves electrical properties (EPs) by solving a linear partial differential equation with discriminated L1 and L2 norm regularization informed by intermediate EP gradient. The theory of CONCEPT and a fast reconstruction algorithm based on the alternating direction method of multipliers are described and evaluated using numerical simulations, phantom experiment, and analysis of in vivo human brain data at 7 T MRI. Compared with the multi-channel gradient-based EPT (gEPT) method, this new technology does not require receive- B1 sensitivity profiles and does not rely on symmetry assumption regarding RF coil design and imaged target. Moreover, it is not dependent on external prior information, such as integration seed point or anatomical MRI, which can be sources of bias in reconstructed EP values. By deriving EPs from transmit B1 profiles only, CONCEPT can be used with RF coils that include receive-only arrays with large channel count which can, in turn, offer substantial gains in signal-to-noise ratio. It also holds potentials to image unsymmetrical body organs and diseased brain. CONCEPT provides solutions for the practical problems during the implementation of gEPT, thus representing a more generalized framework in the context of multi-channel RF transmission.