| Literature DB >> 30093597 |
Matthew D Young1, Thomas J Mitchell1,2,3, Felipe A Vieira Braga1, Maxine G B Tran4,5, Benjamin J Stewart6, John R Ferdinand6, Grace Collord1,2,7, Rachel A Botting8, Dorin-Mirel Popescu8, Kevin W Loudon6, Roser Vento-Tormo1, Emily Stephenson8, Alex Cagan1, Sarah J Farndon1,9,10, Martin Del Castillo Velasco-Herrera1, Charlotte Guzzo1, Nathan Richoz6, Lira Mamanova1, Tevita Aho2, James N Armitage3, Antony C P Riddick3, Imran Mushtaq9, Stephen Farrell2, Dyanne Rampling9, James Nicholson2,7, Andrew Filby8, Johanna Burge2, Steven Lisgo11, Patrick H Maxwell12, Susan Lindsay11, Anne Y Warren2, Grant D Stewart2,3, Neil Sebire9,10, Nicholas Coleman2,13, Muzlifah Haniffa14,15, Sarah A Teichmann16, Menna Clatworthy17,6, Sam Behjati16,2,7.
Abstract
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors.Entities:
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Year: 2018 PMID： 30093597 PMCID： PMC6104812 DOI： 10.1126/science.aat1699
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714