Literature DB >> 32359162

Summary From the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research.

Toni K Choueiri1, Michael B Atkins2, Ziad Bakouny1, Maria I Carlo3, Charles G Drake4, Eric Jonasch5, Payal Kapur6, Bryan Lewis7, W Marston Linehan8, Michael J Mitchell9, Sumanta K Pal10, Kevin Pels1, Susan Poteat7, W Kimryn Rathmell11, Brian I Rini11, Sabina Signoretti1,12, Nizar Tannir5, Robert Uzzo13, Christopher G Wood14, Hans J Hammers6.   

Abstract

Kidney cancer is one of the 10 most common cancers both in the United States and worldwide. Until this year, there had not previously been a conference focused on translational studies in the broad and heterogeneous group of kidney cancers. Therefore, a group of researchers, clinicians, and patient advocates dedicated to renal cell carcinoma launched the Kidney Cancer Research Summit (KCRS) to spur collaboration and further therapeutic advances in these tumors. This commentary aims to summarize the oral presentations and serve as a record for future iterations of this meeting. The KCRS sessions addressed the tumor microenvironment, novel methods of drug delivery, single cell sequencing strategies, novel immune checkpoint blockade and cellular therapies, predictive biomarkers, and rare variants of kidney cancers. In addition, the meeting included 2 sessions to promote scientific mentoring and kidney cancer research collaborations. A subsequent KCRS will be planned for the fall of 2020.
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Entities:  

Year:  2021        PMID: 32359162      PMCID: PMC7936057          DOI: 10.1093/jnci/djaa064

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN: 0027-8874            Impact factor:   13.506


  54 in total

1.  CD70 expression patterns in renal cell carcinoma.

Authors:  Lucia B Jilaveanu; Joshua Sznol; Saadia A Aziz; Dylan Duchen; Harriet M Kluger; Robert L Camp
Journal:  Hum Pathol       Date:  2012-03-07       Impact factor: 3.466

2.  Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial.

Authors:  Andrew J Armstrong; Susan Halabi; Tim Eisen; Samuel Broderick; Walter M Stadler; Robert J Jones; Jorge A Garcia; Ulka N Vaishampayan; Joel Picus; Robert E Hawkins; John D Hainsworth; Christian K Kollmannsberger; Theodore F Logan; Igor Puzanov; Lisa M Pickering; Christopher W Ryan; Andrew Protheroe; Christine M Lusk; Sadie Oberg; Daniel J George
Journal:  Lancet Oncol       Date:  2016-01-13       Impact factor: 41.316

3.  Exploiting Uptake of Nanoparticles by Phagocytes for Cancer Treatment.

Authors:  Mee Rie Sheen; Steven Fiering
Journal:  Methods Mol Biol       Date:  2017

4.  Antibody and fragment-based PET imaging of CTLA-4+ T-cells in humanized mouse models.

Authors:  Emily B Ehlerding; Hye Jin Lee; Dawei Jiang; Carolina A Ferreira; Christopher D Zahm; Peng Huang; Jonathan W Engle; Douglas G McNeel; Weibo Cai
Journal:  Am J Cancer Res       Date:  2019-01-01       Impact factor: 6.166

5.  Scaffolding kidney organoids on silk.

Authors:  Ashwani Kumar Gupta; Jeannine M Coburn; Jessica Davis-Knowlton; Erica Kimmerling; David L Kaplan; Leif Oxburgh
Journal:  J Tissue Eng Regen Med       Date:  2019-03-21       Impact factor: 3.963

6.  An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.

Authors:  Richard Tavaré; Helena Escuin-Ordinas; Stephen Mok; Melissa N McCracken; Kirstin A Zettlitz; Felix B Salazar; Owen N Witte; Antoni Ribas; Anna M Wu
Journal:  Cancer Res       Date:  2015-11-16       Impact factor: 12.701

Review 7.  FLCN: The causative gene for Birt-Hogg-Dubé syndrome.

Authors:  Laura S Schmidt; W Marston Linehan
Journal:  Gene       Date:  2017-09-29       Impact factor: 3.688

8.  Dual Chromatin and Cytoskeletal Remodeling by SETD2.

Authors:  In Young Park; Reid T Powell; Durga Nand Tripathi; Ruhee Dere; Thai H Ho; T Lynne Blasius; Yun-Chen Chiang; Ian J Davis; Catherine C Fahey; Kathryn E Hacker; Kristen J Verhey; Mark T Bedford; Eric Jonasch; W Kimryn Rathmell; Cheryl Lyn Walker
Journal:  Cell       Date:  2016-08-11       Impact factor: 41.582

9.  Analysis of VISTA expression and function in renal cell carcinoma highlights VISTA as a potential target for immunotherapy.

Authors:  Shanjuan Hong; Qing Yuan; Haizhui Xia; Genzhen Zhu; Yu Feng; Qiang Wang; Zhiyin Zhang; Wei He; Jian Lu; Chen Dong; Ling Ni
Journal:  Protein Cell       Date:  2019-11       Impact factor: 14.870

10.  The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Authors:  Christopher J Ricketts; Aguirre A De Cubas; Huihui Fan; Christof C Smith; Martin Lang; Ed Reznik; Reanne Bowlby; Ewan A Gibb; Rehan Akbani; Rameen Beroukhim; Donald P Bottaro; Toni K Choueiri; Richard A Gibbs; Andrew K Godwin; Scott Haake; A Ari Hakimi; Elizabeth P Henske; James J Hsieh; Thai H Ho; Rupa S Kanchi; Bhavani Krishnan; David J Kwiatkowski; Wembin Lui; Maria J Merino; Gordon B Mills; Jerome Myers; Michael L Nickerson; Victor E Reuter; Laura S Schmidt; C Simon Shelley; Hui Shen; Brian Shuch; Sabina Signoretti; Ramaprasad Srinivasan; Pheroze Tamboli; George Thomas; Benjamin G Vincent; Cathy D Vocke; David A Wheeler; Lixing Yang; William Y Kim; A Gordon Robertson; Paul T Spellman; W Kimryn Rathmell; W Marston Linehan
Journal:  Cell Rep       Date:  2018-04-03       Impact factor: 9.423

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  8 in total

1.  Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma.

Authors:  Thomas Denize; Yue Hou; Jean-Christophe Pignon; Emily Walton; Destiny J West; Gordon J Freeman; David A Braun; Catherine J Wu; Saurabh Gupta; Robert J Motzer; Michael B Atkins; David McDermott; Toni K Choueiri; Sachet A Shukla; Sabina Signoretti
Journal:  Clin Cancer Res       Date:  2022-09-15       Impact factor: 13.801

2.  Biomarker-Based Phase II Study of Sapanisertib (TAK-228): An mTORC1/2 Inhibitor in Patients With Refractory Metastatic Renal Cell Carcinoma.

Authors:  Bradley A McGregor; Wanling Xie; Elio Adib; Walter M Stadler; Yousef Zakharia; Aijai Alva; M Dror Michaelson; Shilpa Gupta; Elaine T Lam; Subrina Farah; Amin H Nassar; Xiao X Wei; Kerry L Kilbridge; Lauren Harshman; Sabina Signoretti; Lynette Sholl; David J Kwiatkowski; Rana R McKay; Toni K Choueiri
Journal:  JCO Precis Oncol       Date:  2022-02

3.  From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit.

Authors:  Toni K Choueiri; Laurence Albiges; Michael B Atkins; Ziad Bakouny; Gennady Bratslavsky; David A Braun; Naomi B Haas; John B A G Haanen; A Ari Hakimi; Michael A S Jewett; Eric Jonasch; William G Kaelin; Payal Kapur; Chris Labaki; Bryan Lewis; David F McDermott; Sumanta K Pal; Kevin Pels; Susan Poteat; Thomas Powles; W Kimryn Rathmell; Brian I Rini; Sabina Signoretti; Nizar M Tannir; Robert G Uzzo; Hans J Hammers
Journal:  Clin Cancer Res       Date:  2022-03-01       Impact factor: 13.801

Review 4.  First-Line Treatments for Metastatic Clear Cell Renal Cell Carcinoma: An Ever-Enlarging Landscape.

Authors:  Shuchi Gulati; Chris Labaki; Georgia Sofia Karachaliou; Toni K Choueiri; Tian Zhang
Journal:  Oncologist       Date:  2022-03-04       Impact factor: 5.837

Review 5.  Microfluidic formulation of nanoparticles for biomedical applications.

Authors:  Sarah J Shepherd; David Issadore; Michael J Mitchell
Journal:  Biomaterials       Date:  2021-04-26       Impact factor: 15.304

6.  Biomarker analysis from CheckMate 214: nivolumab plus ipilimumab versus sunitinib in renal cell carcinoma.

Authors:  Robert J Motzer; Toni K Choueiri; David F McDermott; Thomas Powles; Yann-Alexandre Vano; Saurabh Gupta; Jin Yao; Celine Han; Ron Ammar; Simon Papillon-Cavanagh; Shruti S Saggi; M Brent McHenry; Petra Ross-Macdonald; Megan Wind-Rotolo
Journal:  J Immunother Cancer       Date:  2022-03       Impact factor: 12.469

7.  A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy.

Authors:  Florian A Büttner; Stefan Winter; Jens Bedke; Matthias Schwab; Elke Schaeffeler; Viktoria Stühler; Steffen Rausch; Jörg Hennenlotter; Susanne Füssel; Stefan Zastrow; Matthias Meinhardt; Marieta Toma; Carmen Jerónimo; Rui Henrique; Vera Miranda-Gonçalves; Nils Kröger; Silvia Ribback; Arndt Hartmann; Abbas Agaimy; Christine Stöhr; Iris Polifka; Falko Fend; Marcus Scharpf; Eva Comperat; Gabriel Wasinger; Holger Moch; Arnulf Stenzl; Marco Gerlinger
Journal:  Genome Med       Date:  2022-09-15       Impact factor: 15.266

8.  COVID-19 impact on early career investigators: a call for action.

Authors:  Ross L Levine; W Kimryn Rathmell
Journal:  Nat Rev Cancer       Date:  2020-07       Impact factor: 69.800

  8 in total

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