| Literature DB >> 30930166 |
Deanne M Taylor1, Bruce J Aronow2, Kai Tan3, Kathrin Bernt4, Nathan Salomonis5, Casey S Greene6, Alina Frolova7, Sarah E Henrickson8, Andrew Wells9, Liming Pei10, Jyoti K Jaiswal11, Jeffrey Whitsett12, Kathryn E Hamilton13, Sonya A MacParland14, Judith Kelsen13, Robert O Heuckeroth15, S Steven Potter16, Laura A Vella17, Natalie A Terry13, Louis R Ghanem13, Benjamin C Kennedy18, Ingo Helbig19, Kathleen E Sullivan8, Leslie Castelo-Soccio20, Arnold Kreigstein21, Florian Herse22, Martijn C Nawijn23, Gerard H Koppelman24, Melissa Haendel25, Nomi L Harris26, Jo Lynne Rokita27, Yuanchao Zhang28, Aviv Regev29, Orit Rozenblatt-Rosen30, Jennifer E Rood30, Timothy L Tickle31, Roser Vento-Tormo32, Saif Alimohamed5, Monkol Lek33, Jessica C Mar34, Kathleen M Loomes13, David M Barrett4, Prech Uapinyoying35, Alan H Beggs36, Pankaj B Agrawal37, Yi-Wen Chen11, Amanda B Muir13, Lana X Garmire38, Scott B Snapper39, Javad Nazarian11, Steven H Seeholzer40, Hossein Fazelinia41, Larry N Singh42, Robert B Faryabi43, Pichai Raman27, Noor Dawany27, Hongbo Michael Xie27, Batsal Devkota27, Sharon J Diskin4, Stewart A Anderson44, Eric F Rappaport45, William Peranteau46, Kathryn A Wikenheiser-Brokamp47, Sarah Teichmann48, Douglas Wallace49, Tao Peng50, Yang-Yang Ding4, Man S Kim27, Yi Xing51, Sek Won Kong52, Carsten G Bönnemann53, Kenneth D Mandl52, Peter S White5.
Abstract
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.Entities:
Mesh：
Year: 2019 PMID： 30930166 PMCID： PMC6616346 DOI： 10.1016/j.devcel.2019.03.001
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270