Literature DB >> 3000288

Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.

F Rapp, H Wrzos.   

Abstract

The nonionic surfactant nonoxynol 9 (NP9), in combination with human alpha interferon, synergistically reduced the titer of herpes simplex virus type 2 (HSV-2) in vitro. The degree of synergy was highest at an interferon concentration of 10(3) IU/ml and an NP9 dilution of 1:1,500. We postulate that NP9 inactivates extracellular HSV-2, whereas interferon inhibits HSV-2 replication at the intracellular level.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3000288      PMCID： PMC180273          DOI： 10.1128/AAC.28.3.449

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Nonoxynol 9 cream for genital herpes simplex.

Authors:  H J Donsky
Journal:  N Engl J Med       Date:  1979-02-15       Impact factor: 91.245

2.  Inactivation of herpes simplex viruses by nonionic surfactants.

Authors:  S S Asculai; M T Weis; M W Rancourt; A B Kupferberg
Journal:  Antimicrob Agents Chemother       Date:  1978-04       Impact factor: 5.191

3.  Synergistic antiviral effects of antiherpes compounds and human leukocyte interferon on varicella-zoster virus in vitro.

Authors:  M Baba; M Ito; S Shigeta; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

4.  Clinical course and diagnosis of genital herpes simplex virus infection and evaluation of topical surfactant therapy.

Authors:  L A Vontver; W C Reeves; M Rattray; L Corey; M A Remington; E Tolentino; A Schweid; K K Holmes
Journal:  Am J Obstet Gynecol       Date:  1979-03-01       Impact factor: 8.661

5.  Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2.

Authors:  T L Stanwick; R F Schinazi; D E Campbell; A J Nahmias
Journal:  Antimicrob Agents Chemother       Date:  1981-04       Impact factor: 5.191

6.  Inhibition of human herpesviruses by combination of acyclovir and human leukocyte interferon.

Authors:  M J Levin; P L Leary
Journal:  Infect Immun       Date:  1981-06       Impact factor: 3.441

7.  Effects of acyclovir combined with other antiviral agents on human cytomegalovirus.

Authors:  S A Spector; M Tyndall; E Kelley
Journal:  Am J Med       Date:  1982-07-20       Impact factor: 4.965

8.  Combined interaction of antiherpes substances and interferon beta on the multiplication of herpes simplex virus.

Authors:  C Janz; R Wigand
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

9.  Potent synergistic inhibition of herpes simplex virus-2 by 9-[(1, 3-dihydroxy-2-propoxy)methyl]guanine in combination with recombinant interferons.

Authors:  D A Eppstein; Y V Marsh
Journal:  Biochem Biophys Res Commun       Date:  1984-04-16       Impact factor: 3.575

10.  VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION.

Authors:  F RAPP
Journal:  J Bacteriol       Date:  1963-11       Impact factor: 3.490
View more
  4 in total

1.  Solubilization and in vitro spermicidal assessment of nonoxynol-9 and selected fractions using rabbit spermatozoa.

Authors:  B A Walter; A A Hawi; P M Zavos; G A Digenis
Journal:  Pharm Res       Date:  1991-03       Impact factor: 4.200

2.  Comparison of intramuscular recombinant alpha interferon (rIFN-2A) with topical acyclovir for the treatment of first-episode herpes genitalis and prevention of recurrences.

Authors:  M J Levin; F N Judson; L Eron; Y J Bryson; L Corey; M Murray; R R Scheer
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

3.  A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses.

Authors:  M K Howett; E B Neely; N D Christensen; B Wigdahl; F C Krebs; D Malamud; S D Patrick; M D Pickel; P A Welsh; C A Reed; M G Ward; L R Budgeon; J W Kreider
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191

Review 4.  Sexually transmitted viruses.

Authors:  F Rapp
Journal:  Yale J Biol Med       Date:  1989 Mar-Apr
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.