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Literature DB >> 1647007

Solubilization and in vitro spermicidal assessment of nonoxynol-9 and selected fractions using rabbit spermatozoa.

B A Walter¹, A A Hawi, P M Zavos, G A Digenis.

Abstract

Selected oligomers representing the high, medium, and low molecular weight fractions of the spermicidal agent Nonoxynol-9 (N-9) were separated by HPLC. Nonoxynol-9 and the isolated fractions were formulated with polyvinylpyrrolidone (PVP) in order to increase their water solubility, particularly that of the insoluble low molecular weight fraction. The in vitro spermicidal activity of three molecular weight fractions were compared to that of N-9, using rabbit spermatozoa, at equimolar concentrations. Nonoxynol-9/PVP was far more effective in immobilizing the sperm than either N-9 alone or the separate fractions. The relative spermicidal activity of the oligomers was of the order middle molecular weight greater than high molecular weight greater than low molecular weight.

Entities: Chemical Species

Mesh：

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Year: 1991 PMID： 1647007 DOI： 10.1023/a:1015818220894

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

20 in total

1. Dissolution rates of high energy sulfathiazole--povidone coprecipitates II: characterization of form of drug controlling its dissolution rate via solubility studies.

Authors: A P Simonelli; S C Mehta; W I Higuchi
Journal: J Pharm Sci Date: 1976-03 Impact factor: 3.534

2. The effect of Triton X-100 on the ultrastructure of ejaculated bovine sperm.

Authors: F B Wooding
Journal: J Ultrastruct Res Date: 1973-03

3. Inactivation of HIV by nonoxynol-9.

Authors: M Malkovsky; A Newell; A G Dalgleish
Journal: Lancet Date: 1988-03-19 Impact factor: 79.321

4. Nonoxynol-9 and HTLV-III.

Authors: B Voeller
Journal: Lancet Date: 1986-05-17 Impact factor: 79.321

5. Inactivation of HTLV-III/LAV-infected cultures of normal human lymphocytes by nonoxynol-9 in vitro.

Authors: D R Hicks; L S Martin; J P Getchell; J L Heath; D P Francis; J S McDougal; J W Curran; B Voeller
Journal: Lancet Date: 1985 Dec 21-28 Impact factor: 79.321

6. Studies on the development of a vaginal preparation providing both prophylaxis against venereal disease and other genital infections and contraception. II. Effect in vitro of vaginal contraceptive and non-contraceptive preparations on Treponema pallidum and Neisseria gonorrhoeae.

Authors: B Singh; J C Cutler; H M Utidjian
Journal: Br J Vener Dis Date: 1972-02

1. Coprecipitation of nonoxynol-9 with polyvinylpyrrolidone to decrease vaginal irritation potential while maintaining spermicidal potency.

Authors: Philip T Fowler; Gustavo F Doncel; Paul M Bummer; George A Digenis
Journal: AAPS PharmSciTech Date: 2003 Impact factor: 3.246

1 in total

Solubilization and in vitro spermicidal assessment of nonoxynol-9 and selected fractions using rabbit spermatozoa.

1. Dissolution rates of high energy sulfathiazole--povidone coprecipitates II: characterization of form of drug controlling its dissolution rate via solubility studies.

2. The effect of Triton X-100 on the ultrastructure of ejaculated bovine sperm.

3. Inactivation of HIV by nonoxynol-9.

4. Nonoxynol-9 and HTLV-III.

5. Inactivation of HTLV-III/LAV-infected cultures of normal human lymphocytes by nonoxynol-9 in vitro.

6. Studies on the development of a vaginal preparation providing both prophylaxis against venereal disease and other genital infections and contraception. II. Effect in vitro of vaginal contraceptive and non-contraceptive preparations on Treponema pallidum and Neisseria gonorrhoeae.

7. Treatment of recurrent genital herpes with topical alpha interferon gel combined with nonoxynol 9.

8. Excretion of certain polyethylene glycol ether adducts of nonylphenol by the rat.

9. Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.

10. A case-control study of spermicides and gonorrhea.

1. Coprecipitation of nonoxynol-9 with polyvinylpyrrolidone to decrease vaginal irritation potential while maintaining spermicidal potency.