Literature DB >> 2993661

Demonstration of an immunodominant neutralization site by analysis of antigenic variants of SA11 rotavirus.

I Lazdins, S Sonza, M L Dyall-Smith, B S Coulson, I H Holmes.   

Abstract

Serotype-specific monoclonal antibodies were used to select mutants of SA11 rotavirus that were resistant to neutralization. The antigenic characteristics of these mutants were studied with with a panel of monoclonal antibodies. We isolated one type of mutant which showed a dramatic increase (greater than 10-fold) in resistance to neutralization by hyperimmune antiserum, and this together with other data indicates the presence on the rotavirus major outer shell glycoprotein of an immunodominant antigenic site involved in virus neutralization. The mutants were also useful in classifying neutralizing monoclonal antibodies.

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Year:  1985        PMID： 2993661      PMCID： PMC252539     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  13 in total

1.  The major surface glycoprotein of simian rotavirus (SA11) contains distinct epitopes.

Authors:  S Sonza; A M Breschkin; I H Holmes
Journal:  Virology       Date:  1984-04-30       Impact factor: 3.616

2.  Preparation and characterization of antisera to electrophoretically purified SA11 virus polypeptides.

Authors:  J W Bastardo; J L McKimm-Breschkin; S Sonza; L D Mercer; I H Holmes
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

3.  Genes of human (strain Wa) and bovine (strain UK) rotaviruses that code for neutralization and subgroup antigens.

Authors:  A R Kalica; H B Greenberg; R G Wyatt; J Flores; M M Sereno; A Z Kapikian; R M Chanock
Journal:  Virology       Date:  1981-07-30       Impact factor: 3.616

4.  Gene-coding assignments of rotavirus double-stranded RNA segments 10 and 11.

Authors:  M L Dyall-Smith; I H Holmes
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

5.  Gene mapping of rotavirus double-stranded RNA segments by northern blot hybridization: application to segments 7, 8, and 9.

Authors:  M L Dyall-Smith; A A Azad; I H Holmes
Journal:  J Virol       Date:  1983-04       Impact factor: 5.103

6.  Serotyping and subgrouping of rotavirus strains by the ELISA test.

Authors:  M E Thouless; G M Beards; T H Flewett
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

7.  Sequence homology between human and animal rotavirus serotype-specific glycoproteins.

Authors:  M L Dyall-Smith; I H Holmes
Journal:  Nucleic Acids Res       Date:  1984-05-11       Impact factor: 16.971

8.  Production and preliminary characterization of monoclonal antibodies directed at two surface proteins of rhesus rotavirus.

Authors:  H B Greenberg; J Valdesuso; K van Wyke; K Midthun; M Walsh; V McAuliffe; R G Wyatt; A R Kalica; J Flores; Y Hoshino
Journal:  J Virol       Date:  1983-08       Impact factor: 5.103

9.  Coding assignments of double-stranded RNA segments of SA 11 rotavirus established by in vitro translation.

Authors:  M L Smith; I Lazdins; I H Holmes
Journal:  J Virol       Date:  1980-03       Impact factor: 5.103

10.  Completion of the gene coding assignments of SA11 rotavirus: gene products of segments 7, 8, and 9.

Authors:  P Kantharidis; M L Dyall-Smith; I H Holmes
Journal:  J Virol       Date:  1983-10       Impact factor: 5.103
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  21 in total

1.  Detection of human group C rotaviruses by an enzyme-linked immunosorbent assay using monoclonal antibodies.

Authors:  R Fujii; M Kuzuya; M Hamano; M Yamada; S Yamazaki
Journal:  J Clin Microbiol       Date:  1992-05       Impact factor: 5.948

2.  Operational overlapping of cross-reactive and serotype-specific neutralization epitopes on VP7 of human rotavirus serotype 3.

Authors:  N Kobayashi; K Taniguchi; S Urasawa
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

3.  Relation of VP7 amino acid sequence to monoclonal antibody neutralization of rotavirus and rotavirus monotype.

Authors:  B S Coulson; C Kirkwood
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

4.  Location of the major antigenic sites involved in rotavirus serotype-specific neutralization.

Authors:  M L Dyall-Smith; I Lazdins; G W Tregear; I H Holmes
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

5.  Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.

Authors:  C D Kirkwood; R F Bishop; B S Coulson
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

6.  Non-neutralizing monoclonal antibodies to a trypsin-sensitive site on the major glycoprotein of rotavirus which discriminate between virus serotypes.

Authors:  B S Coulson; K J Fowler; J R White; R G Cotton
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

7.  Simple and specific enzyme immunoassay using monoclonal antibodies for serotyping human rotaviruses.

Authors:  B S Coulson; L E Unicomb; G A Pitson; R F Bishop
Journal:  J Clin Microbiol       Date:  1987-03       Impact factor: 5.948

8.  Genetic stability of rotaviruses recovered from asymptomatic neonatal infections.

Authors:  J Flores; J Sears; K Y Green; I Perez-Schael; A Morantes; G Daoud; M Gorziglia; Y Hoshino; R M Chanock; A Z Kapikian
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

9.  Marked sequence variation between segment 4 genes of human RV-5 and simian SA 11 rotaviruses.

Authors:  P Kantharidis; M L Dyall-Smith; I H Holmes
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

10.  Serologic analysis of human rotavirus serotypes P1A and P2 by using monoclonal antibodies.

Authors:  L Padilla-Noriega; R Werner-Eckert; E R Mackow; M Gorziglia; G Larralde; K Taniguchi; H B Greenberg
Journal:  J Clin Microbiol       Date:  1993-03       Impact factor: 5.948
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