Literature DB >> 29932943

Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls.

John Paul Shen1, Trey Ideker2.   

Abstract

Synthetic lethal interactions, in which the simultaneous loss of function of two genes produces a lethal phenotype, are being explored as a means to therapeutically exploit cancer-specific vulnerabilities and expand the scope of precision oncology. Currently, three Food and Drug Administration-approved drugs work by targeting the synthetic lethal interaction between BRCA1/2 and PARP. This review examines additional efforts to discover networks of synthetic lethal interactions and discusses both challenges and opportunities regarding the translation of new synthetic lethal interactions into the clinic.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cancer genomics; genetic interaction; precision medicine; synthetic lethal; systems biology

Mesh：

Substances：

Year:  2018        PMID： 29932943      PMCID： PMC6097899          DOI： 10.1016/j.jmb.2018.06.026

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  136 in total

1.  Hitting the Target in BRAF-Mutant Colorectal Cancer.

Authors:  Ankur K Nagaraja; Adam J Bass
Journal:  J Clin Oncol       Date:  2015-10-12       Impact factor: 44.544

2.  Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Authors:  Maya Schuldiner; Sean R Collins; Natalie J Thompson; Vladimir Denic; Arunashree Bhamidipati; Thanuja Punna; Jan Ihmels; Brenda Andrews; Charles Boone; Jack F Greenblatt; Jonathan S Weissman; Nevan J Krogan
Journal:  Cell       Date:  2005-11-04       Impact factor: 41.582

3.  Genetic interaction mapping in mammalian cells using CRISPR interference.

Authors:  Dan Du; Assen Roguev; David E Gordon; Meng Chen; Si-Han Chen; Michael Shales; John Paul Shen; Trey Ideker; Prashant Mali; Lei S Qi; Nevan J Krogan
Journal:  Nat Methods       Date:  2017-05-08       Impact factor: 28.547

Review 4.  Cas9 as a versatile tool for engineering biology.

Authors:  Prashant Mali; Kevin M Esvelt; George M Church
Journal:  Nat Methods       Date:  2013-10       Impact factor: 28.547

Review 5.  Integrating genetic approaches into the discovery of anticancer drugs.

Authors:  L H Hartwell; P Szankasi; C J Roberts; A W Murray; S H Friend
Journal:  Science       Date:  1997-11-07       Impact factor: 47.728

6.  Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.

Authors:  Dongxin Zhao; Mehmet G Badur; Jens Luebeck; Jose H Magaña; Amanda Birmingham; Roman Sasik; Christopher S Ahn; Trey Ideker; Christian M Metallo; Prashant Mali
Journal:  Mol Cell       Date:  2018-02-15       Impact factor: 17.970

7.  A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity.

Authors:  Stephen J Pettitt; Farah L Rehman; Ilirjana Bajrami; Rachel Brough; Fredrik Wallberg; Iwanka Kozarewa; Kerry Fenwick; Ioannis Assiotis; Lina Chen; James Campbell; Christopher J Lord; Alan Ashworth
Journal:  PLoS One       Date:  2013-04-25       Impact factor: 3.240

8.  CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer.

Authors:  Mark D M Leiserson; Hsin-Ta Wu; Fabio Vandin; Benjamin J Raphael
Journal:  Genome Biol       Date:  2015-08-08       Impact factor: 13.583

9.  Network-based stratification of tumor mutations.

Authors:  Matan Hofree; John P Shen; Hannah Carter; Andrew Gross; Trey Ideker
Journal:  Nat Methods       Date:  2013-09-15       Impact factor: 28.547

Review 10.  PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers.

Authors:  Mekonnen Sisay; Dumessa Edessa
Journal:  Gynecol Oncol Res Pract       Date:  2017-11-29
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  12 in total

Review 1.  Genetic interaction networks in cancer cells.

Authors:  Barbara Mair; Jason Moffat; Charles Boone; Brenda J Andrews
Journal:  Curr Opin Genet Dev       Date:  2019-04-08       Impact factor: 5.578

2.  Identification of Synthetic Lethal Interactions Using High-Throughput, Arrayed CRISPR/Cas9-Based Platforms.

Authors:  MacKenzie J MacAuley; Omar Abuhussein; Frederick S Vizeacoumar
Journal:  Methods Mol Biol       Date:  2021

3.  A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities.

Authors:  Ravi S Narayan; Piet Molenaar; Jian Teng; Fleur M G Cornelissen; Irene Roelofs; Renee Menezes; Rogier Dik; Tonny Lagerweij; Yoran Broersma; Naomi Petersen; Jhon Alexander Marin Soto; Eelke Brands; Philip van Kuiken; Maria C Lecca; Kristiaan J Lenos; Sjors G J G In 't Veld; Wessel van Wieringen; Frederick F Lang; Erik Sulman; Roel Verhaak; Brigitta G Baumert; Lucas J A Stalpers; Louis Vermeulen; Colin Watts; David Bailey; Ben J Slotman; Rogier Versteeg; David Noske; Peter Sminia; Bakhos A Tannous; Tom Wurdinger; Jan Koster; Bart A Westerman
Journal:  Nat Commun       Date:  2020-06-10       Impact factor: 14.919

Review 4.  Integrating molecular networks with genetic variant interpretation for precision medicine.

Authors:  Emidio Capriotti; Kivilcim Ozturk; Hannah Carter
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2018-12-12

5.  A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity.

Authors:  Sean M Santos; Mert Icyuz; Ilya Pound; Doreen William; Jingyu Guo; Brett A McKinney; Michael Niederweis; John Rodgers; John L Hartman
Journal:  Genes (Basel)       Date:  2019-09-30       Impact factor: 4.096

6.  FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.

Authors:  Elaine Guo; Yuki Ishii; James Mueller; Anjana Srivatsan; Timothy Gahman; Christopher D Putnam; Jean Y J Wang; Richard D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-27       Impact factor: 11.205

Review 7.  Artificial intelligence, molecular subtyping, biomarkers, and precision oncology.

Authors:  John Paul Shen
Journal:  Emerg Top Life Sci       Date:  2021-12-21

8.  Conditional transcriptional relationships may serve as cancer prognostic markers.

Authors:  Hui Yu; Limei Wang; Danqian Chen; Jin Li; Yan Guo
Journal:  BMC Med Genomics       Date:  2021-12-02       Impact factor: 3.063

9.  Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2.

Authors:  Melanie L Bailey; David Tieu; Andrea Habsid; Amy Hin Yan Tong; Katherine Chan; Jason Moffat; Philip Hieter
Journal:  Life Sci Alliance       Date:  2021-08-30

10.  Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network.

Authors:  Albi Celaj; Marinella Gebbia; Louai Musa; Atina G Cote; Jamie Snider; Victoria Wong; Minjeong Ko; Tiffany Fong; Paul Bansal; Joseph C Mellor; Gireesh Seesankar; Maria Nguyen; Shijie Zhou; Liangxi Wang; Nishka Kishore; Igor Stagljar; Yo Suzuki; Nozomu Yachie; Frederick P Roth
Journal:  Cell Syst       Date:  2019-10-23       Impact factor: 10.304
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