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Literature DB >> 2991117

The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.

D J Shaw, A L Meredith, M Sarfarazi, S M Huson, J D Brook, O Myklebost, P S Harper.

Abstract

The human apolipoprotein CII gene probe detects a restriction fragment length polymorphism located on chromosome 19. We have investigated the linkage of this polymorphism to the myotonic dystrophy locus in families. The two loci are closely linked with a maximum Lod score of 7.877 at 4% recombination. The close linkage and informativeness of the APOC2 polymorphism suggest that this probe may be of use for presymptomatic diagnosis of the myotonic dystrophy gene. The APOC2 gene was localised to the region 19p13-19q13 using somatic cell hybrids, providing further evidence that the myotonic dystrophy locus is situated in the central region of chromosome 19.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1985 PMID： 2991117 DOI： 10.1007/bf00273455

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

12 in total

1. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

Review 2. Report of the Committee on the Genetic Constitution of Chromosomes 18, 19, 20, 21, and 22.

Authors: A Westerveld; S Naylor
Journal: Cytogenet Cell Genet Date: 1984

3. The isolation and characterization of cDNA clones for human apolipoprotein CII.

Authors: O Myklebost; B Williamson; A F Markham; S R Myklebost; J Rogers; D E Woods; S E Humphries
Journal: J Biol Chem Date: 1984-04-10 Impact factor: 5.157

4. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

5. Genetic linkage between the loci for myotonic dystrophy and peptidase D.

Authors: T O'Brien; S Ball; M Sarfarazi; P S Harper; E B Robson
Journal: Ann Hum Genet Date: 1983-05 Impact factor: 1.670

6. Localisation of genetic markers and orientation of the linkage group on chromosome 19.

Authors: J D Brook; D J Shaw; L Meredith; G A Bruns; P S Harper
Journal: Hum Genet Date: 1984 Impact factor: 4.132

7. Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.

Authors: C L Jackson; G A Bruns; J L Breslow
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

8. The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man.

Authors: O Myklebost; S Rogne; B Olaisen; T Gedde-Dahl; H Prydz
Journal: Hum Genet Date: 1984 Impact factor: 4.132

9. Genetics and linkage relationships of the C3 polymorphism: discovery of C3-Se linkage and assignment of LES-C3-DM-Se-PEPD-Lu synteny to chromosome 19.

Authors: H Eiberg; J Mohr; L S Nielsen; N Simonsen
Journal: Clin Genet Date: 1983-09 Impact factor: 4.438

10. The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19.

Authors: T Gedde-Dahl; B Olaisen; P Teisberg; M C Wilhelmy; B Mevåg; R Helland
Journal: Hum Genet Date: 1984 Impact factor: 4.132

28 in total

1. Specific molecular prenatal diagnosis for the CTG mutation in myotonic dystrophy.

Authors: J Myring; A L Meredith; H G Harley; G Kohn; G Norbury; P S Harper; D J Shaw
Journal: J Med Genet Date: 1992-11 Impact factor: 6.318

2. The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

Authors: J D Brook; S J Knight; S H Roberts; H G Harley; K V Walsh; S A Rundle; K Freyne; M C Koch; N D Epstein; B Wieringa
Journal: Hum Genet Date: 1991-05 Impact factor: 4.132

3. Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

Authors: H G Harley; K V Walsh; S Rundle; J D Brook; M Sarfarazi; M C Koch; J L Floyd; P S Harper; D J Shaw
Journal: Hum Genet Date: 1991-05 Impact factor: 4.132

4. Genetic risks for children of women with myotonic dystrophy.

Authors: M C Koch; T Grimm; H G Harley; P S Harper
Journal: Am J Hum Genet Date: 1991-06 Impact factor: 11.025

5. Use of variable simple sequence motifs as genetic markers: application to study of myotonic dystrophy.

Authors: H J Smeets; H G Brunner; H H Ropers; B Wieringa
Journal: Hum Genet Date: 1989-10 Impact factor: 4.132

6. Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites.

Authors: D J Shaw; H G Harley; J D Brook; T W McKeithan
Journal: Hum Genet Date: 1989-08 Impact factor: 4.132