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Literature DB >> 2570021

Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites.

D J Shaw¹, H G Harley, J D Brook, T W McKeithan.

Abstract

The apolipoprotein gene cluster on human chromosome 19 (APOC1, APOC2, APOE) has been localised by pulsed-field gel electrophoresis to within 200 kb of a chronic lymphocytic leukemia-associated translocation breakpoint. A restriction map covering 1300 kb around these loci has been constructed and contains two polymorphic MluI sites, which appear to show Mendelian inheritance. The orientation of the map on the chromosome has been established as 19cen - CLL breakpoint - APOC2 - 19qter. Pedigree analysis using APOC2, a probe derived from the CLL breakpoint, and other localised markers on 19q suggests that the myotonic dystrophy locus is distal to APOC2 on 19q.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2570021 DOI： 10.1007/BF00274152

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

1. Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields.

Authors: D Vollrath; R W Davis
Journal: Nucleic Acids Res Date: 1987-10-12 Impact factor: 16.971

2. A primary map of ten DNA markers and two serological markers for human chromosome 19.

Authors: Y Nakamura; M Lathrop; P O'Connell; M Leppert; J M Lalouel; R White
Journal: Genomics Date: 1988-07 Impact factor: 5.736

3. A physical map of the apolipoprotein gene cluster on human chromosome 19.

Authors: O Myklebost; S Rogne
Journal: Hum Genet Date: 1988-03 Impact factor: 4.132

4. Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19.

Authors: D J Shaw; A L Meredith; M Sarfarazi; H G Harley; S M Huson; J D Brook; L Bufton; M Litt; T Mohandas; P S Harper
Journal: Hum Genet Date: 1986-11 Impact factor: 4.132

5. Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

Authors: C R Sharpe; A Sidoli; C S Shelley; M A Lucero; C C Shoulders; F E Baralle
Journal: Nucleic Acids Res Date: 1984-05-11 Impact factor: 16.971

6. Further mapping of markers around the centromere of human chromosome 19.

Authors: J D Brook; M Skinner; S H Roberts; W J Rettig; J W Almond; D J Shaw
Journal: Genomics Date: 1987-12 Impact factor: 5.736

7. Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair.

Authors: R L Stallings; E Olson; A W Strauss; L H Thompson; L L Bachinski; M J Siciliano
Journal: Am J Hum Genet Date: 1988-08 Impact factor: 11.025

8. Localization of genes encoding apolipoproteins CI, CII, and E to the p13----cen region of human chromosome 19.

Authors: J Scott; T J Knott; D J Shaw; J D Brook
Journal: Hum Genet Date: 1985 Impact factor: 4.132

9. The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.

Authors: D J Shaw; A L Meredith; M Sarfarazi; S M Huson; J D Brook; O Myklebost; P S Harper
Journal: Hum Genet Date: 1985 Impact factor: 4.132

10. Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

Authors: T W McKeithan; J D Rowley; T B Shows; M O Diaz
Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205

10 in total

1. The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

Authors: J D Brook; S J Knight; S H Roberts; H G Harley; K V Walsh; S A Rundle; K Freyne; M C Koch; N D Epstein; B Wieringa
Journal: Hum Genet Date: 1991-05 Impact factor: 4.132

2. Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

Authors: H G Harley; K V Walsh; S Rundle; J D Brook; M Sarfarazi; M C Koch; J L Floyd; P S Harper; D J Shaw
Journal: Hum Genet Date: 1991-05 Impact factor: 4.132

Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites.

1. Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields.

2. A primary map of ten DNA markers and two serological markers for human chromosome 19.

3. A physical map of the apolipoprotein gene cluster on human chromosome 19.

4. Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19.

5. Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

6. Further mapping of markers around the centromere of human chromosome 19.

7. Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair.

8. Localization of genes encoding apolipoproteins CI, CII, and E to the p13----cen region of human chromosome 19.

9. The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.

10. Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

1. The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

2. Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

3. Identification of new DNA markers close to the myotonic dystrophy locus.

4. Detection of linkage disequilibrium between the myotonic dystrophy locus and a new polymorphic DNA marker.

5. The 1.5-Mb region spanning the myotonic dystrophy locus shows uniform recombination frequency.

6. A study of DNA methylation in myotonic dystrophy.

7. A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.

8. Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy.

9. A new polymorphic probe which defines the region of chromosome 19 containing the myotonic dystrophy locus.

10. Computational Methods for Detection of Differentially Methylated Regions Using Kernel Distance and Scan Statistics.