Joseph J Fantony1, Lauren E Howard2,3, Ilona Csizmadi4, Andrew J Armstrong5, Amy L Lark6,7, Colette Galet8,9, William J Aronson8,10, Stephen J Freedland2,4. 1. Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. 2. Urology Section, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA. 3. Department of Biostatistics and Bioinformatics, Duke School of Medicine, Durham, NC 27705, USA. 4. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. 5. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. 6. Department of Pathology, Duke University Hospital, Durham, NC 27710, USA. 7. Department of Pathology, Durham Veterans Affairs Medical Center, Durham, NC 27710, USA. 8. Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. 9. Division of Acute Care Surgery, Department of Surgery, Carver College of Medicine, University of Iowa, IA 52242, USA. 10. Urology Section, Department of Surgery, Greater Los Angeles Veterans Affairs Healthcare System, CA 90073, USA.
Abstract
AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. RESULTS: Ki67 was associated with more recent surgery year (p < 0.001), positive margins (p = 0.001) and extracapsular extension (p < 0.001). In center-stratified analyses, the adjusted HR for Ki67 expression and BCR approached statistical significance for west LA (HR: 1.54; p = 0.06), but not Durham (HR: 1.10; p = 0.74). CONCLUSION: This multi-institutional 'real-world' study provides limited evidence for the prognostic role of Ki67 in predicting outcome after RP.
AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. RESULTS: Ki67 was associated with more recent surgery year (p < 0.001), positive margins (p = 0.001) and extracapsular extension (p < 0.001). In center-stratified analyses, the adjusted HR for Ki67 expression and BCR approached statistical significance for west LA (HR: 1.54; p = 0.06), but not Durham (HR: 1.10; p = 0.74). CONCLUSION: This multi-institutional 'real-world' study provides limited evidence for the prognostic role of Ki67 in predicting outcome after RP.
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