Literature DB >> 2988434

Correlation of aminoglycoside resistance with the KmS and Vmax/Km ratios of enzymatic modification of aminoglycosides by 2''-O-nucleotidyltransferase.

D A DeHertogh, S A Lerner.   

Abstract

A clinical isolate, Serratia marcescens 75, was found to be susceptible to netilmicin and yet had a high level of aminoglycoside 2''-O-nucleotidyltransferase activity for netilmicin. Kinetic studies of the partially purified enzyme revealed substrate inhibition for gentamicin and tobramycin at concentrations greater than 10(-2) mM, but this was not observed for netilmicin. The MICs of the aminoglycosides tested exhibited a good inverse correlation with the Km values for the enzyme and a direct correlation with the Vmax/Km ratios of the enzyme.

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Year:  1985        PMID： 2988434      PMCID： PMC180122          DOI： 10.1128/AAC.27.4.670

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Aminoglycoside-modifying enzymes.

Authors:  M J Haas; J E Dowding
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Authors:  M Haas; S Biddlecome; J Davies; C E Luce; P J Daniels
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

4.  Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Authors:  S Biddlecome; M Haas; J Davies; G H Miller; D F Rane; P J Daniels
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

5.  Correlation of antibiotic resistance with Vmax/Km ratio of enzymatic modification of aminoglycosides by kanamycin acetyltransferase.

Authors:  K Radika; D B Northrop
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

6.  Relation between aminoglycoside 2"-O-nucleotidyltransferase activity and aminoglycoside resistance.

Authors:  G P Bongaerts; L Molendijk
Journal:  Antimicrob Agents Chemother       Date:  1984-02       Impact factor: 5.191

7.  Simplified radioenzymatic assay for chloramphenicol.

Authors:  L R Robison; R Seligsohn; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

8.  5-epi-Sisomicin and 5-epi-Gentamicin B: substrates for aminoglycoside-modifying enzymes that retain activity against aminoglycoside-resistant bacteria.

Authors:  A P Vastola; J Altschaefl; S Harford
Journal:  Antimicrob Agents Chemother       Date:  1980-05       Impact factor: 5.191

9.  Effect of enzymatic adenylylation on dihydrostreptomycin accumulation in Escherichia coli carrying an R-factor: model explaining aminoglycoside resistance by inactivating mechanisms.

Authors:  P Dickie; L E Bryan; M A Pickard
Journal:  Antimicrob Agents Chemother       Date:  1978-10       Impact factor: 5.191
  9 in total
  6 in total

1.  Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes.

Authors:  G P Bongaerts; J S Vliegenthart
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

2.  High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake.

Authors:  M H Perlin; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

Review 3.  Bacterial uptake of aminoglycoside antibiotics.

Authors:  H W Taber; J P Mueller; P F Miller; A S Arrow
Journal:  Microbiol Rev       Date:  1987-12

4.  Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium.

Authors:  G D Wright; P Ladak
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

5.  Pharmacokinetic and pharmacodynamic approach for comparing two therapeutic regimens using amikacin.

Authors:  M Staneva; B Markova; I Atanasova; D Terziivanov
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191

6.  Isolation, characterization, and cloning of a plasmid-borne gene encoding a phosphotransferase that confers high-level amikacin resistance in enteric bacilli.

Authors:  R Gaynes; E Groisman; E Nelson; M Casadaban; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191
  6 in total

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