Literature DB >> 2987860

Functional RNA polymerase II promoters in solitary retroviral long terminal repeats (LTR-IS elements).

K Köhrer, I Grummt, I Horak.   

Abstract

LTR-IS elements are middle repetitive sequences in the mouse genome with structural features of solitary retroviral LTRs. In order to get some insight in the possible functional role of these sequences the promotor activity of two LTR-IS representatives differing by 105 bp in their U3 region was investigated. Gene fusions between LTR-IS sequences and the bacterial gene coding for chloramphenicol acetyl transferase (CAT) were transfected into mouse 3T6 cells and the expression of CAT was measured. It is shown that the LTR-IS sequences represent weak RNA polymerase II promoters which require enhancement by cis-or trans-activating factors.

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Year:  1985        PMID： 2987860      PMCID： PMC341180          DOI： 10.1093/nar/13.7.2631

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  19 in total

1.  Expression of bacterial beta-galactosidase in animal cells.

Authors:  G An; K Hidaka; L Siminovitch
Journal:  Mol Cell Biol       Date:  1982-12       Impact factor: 4.272

2.  Ribonucleic acid isolated by cesium chloride centrifugation.

Authors:  V Glisin; R Crkvenjakov; C Byus
Journal:  Biochemistry       Date:  1974-06-04       Impact factor: 3.162

3.  Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS).

Authors:  M Schmidt; K Glöggler; T Wirth; I Horak
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

4.  In vivo sequence requirements of the SV40 early promotor region.

Authors:  C Benoist; P Chambon
Journal:  Nature       Date:  1981-03-26       Impact factor: 49.962

5.  The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

Authors:  C M Gorman; G T Merlino; M C Willingham; I Pastan; B H Howard
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

6.  Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state.

Authors:  G S Payne; S A Courtneidge; L B Crittenden; A M Fadly; J M Bishop; H E Varmus
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

7.  Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion.

Authors:  B G Neel; W S Hayward; H L Robinson; J Fang; S M Astrin
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

8.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

9.  Simian virus 40 tandem repeated sequences as an element of the early promoter.

Authors:  P Gruss; R Dhar; G Khoury
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  5 in total

1.  Insertion of a retrotransposon within the 3' end of a mouse gene provides a new functional polyadenylation signal.

Authors:  T Baumruker; C Gehe; I Horak
Journal:  Nucleic Acids Res       Date:  1988-08-11       Impact factor: 16.971

2.  The 3' long terminal repeat of a transcribed yet defective endogenous retroviral sequence is a competent promoter of transcription.

Authors:  D E Levy; R D McKinnon; M N Brolaski; J W Gautsch; M C Wilson
Journal:  J Virol       Date:  1987-04       Impact factor: 5.103

3.  Negative regulatory element associated with potentially functional promoter and enhancer elements in the long terminal repeats of endogenous murine leukemia virus-related proviral sequences.

Authors:  L Y Ch'ang; W K Yang; F E Myer; D M Yang
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

4.  Anti-IgM antibodies down modulate mu-enhancer activity and OTF2 levels in LPS-stimulated mouse splenic B-cells.

Authors:  U Chen; R H Scheuermann; T Wirth; T Gerster; R G Roeder; K Harshman; C Berger
Journal:  Nucleic Acids Res       Date:  1991-11-11       Impact factor: 16.971

5.  The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation.

Authors:  Felix Broecker; Roger Horton; Jochen Heinrich; Alexandra Franz; Michal-Ruth Schweiger; Hans Lehrach; Karin Moelling
Journal:  Mob DNA       Date:  2016-12-07
  5 in total

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