Aiguo Han1, Yassin Labyed2, Ethan Z Sy3, Andrew S Boehringer3, Michael P Andre4,5, John W Erdman6, Rohit Loomba7, Claude B Sirlin3, William D O'Brien8. 1. Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 North Wright Street, Urbana, IL, 61801, USA. 2. Siemens Healthineers USA, 22010 South East 51st Street, Issaquah, WA, 98029, USA. 3. Liver Imaging Group, Department of Radiology, University of California at San Diego, 9452 Medical Center Drive, La Jolla, CA, 92037, USA. 4. Department of Radiology, University of California at San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA. 5. San Diego VA Healthcare System, San Diego, CA, USA. 6. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 905 South Goodwin Avenue, Urbana, IL, 61801, USA. 7. NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. 8. Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 North Wright Street, Urbana, IL, 61801, USA. wdo@uiuc.edu.
Abstract
OBJECTIVES: To assess inter-sonographer reproducibility of ultrasound attenuation coefficient (AC), backscatter coefficient (BSC) and shear wave speed (SWS) in adults with known/suspected non-alcoholic fatty liver disease (NAFLD). METHODS: The institutional review board approved this HIPAA-compliant prospective study; informed consent was obtained. Participants with known/suspected NAFLD were recruited and underwent same-day liver examinations with a clinical scanner. Each participant was scanned by two of the six trained sonographers. Each sonographer performed multiple data acquisitions in the right liver lobe using a lateral intercostal approach. A data acquisition was a single operator button press that recorded a B-mode image, radio-frequency data, and the SWS value. AC and BSC were calculated from the radio-frequency data using the reference phantom method. SWS was calculated automatically using product software. Intraclass correlation coefficient (ICC) and within-subject coefficient of variation (wCV) were calculated for applicable metrics. RESULTS: Sixty-one participants were recruited. Inter-sonographer ICC was 0.86 (95% confidence interval: 0.77-0.92) for AC and 0.87 (0.78-0.92) for log-transformed BSC (logBSC = 10log10BSC) using one acquisition per sonographer. ICC was 0.88 (0.80-0.93) for both AC and logBSC averaging 5 acquisitions. ICC for SWS was 0.57 (0.29-0.74) using one acquisition per sonographer, and 0.84 (0.66-0.93) using 10 acquisitions. The wCV was ~7% for AC, and 19-43% for SWS, depending on number of acquisitions. CONCLUSIONS: Hepatic AC, BSC and SWS measures on a clinical scanner have good inter-sonographer reproducibility in adults with known or suspected NAFLD. Multiple acquisitions are required for SWS but not AC or BSC to achieve good inter-sonographer reproducibility. KEY POINTS: • AC, BSC and SWS measurements are reproducible in adults with NAFLD. • Inter-sonographer reproducibility of SWS measurement improves with more acquisitions being averaged. • Multiple acquisitions are required for SWS but not AC or BSC.
OBJECTIVES: To assess inter-sonographer reproducibility of ultrasound attenuation coefficient (AC), backscatter coefficient (BSC) and shear wave speed (SWS) in adults with known/suspected non-alcoholic fatty liver disease (NAFLD). METHODS: The institutional review board approved this HIPAA-compliant prospective study; informed consent was obtained. Participants with known/suspected NAFLD were recruited and underwent same-day liver examinations with a clinical scanner. Each participant was scanned by two of the six trained sonographers. Each sonographer performed multiple data acquisitions in the right liver lobe using a lateral intercostal approach. A data acquisition was a single operator button press that recorded a B-mode image, radio-frequency data, and the SWS value. AC and BSC were calculated from the radio-frequency data using the reference phantom method. SWS was calculated automatically using product software. Intraclass correlation coefficient (ICC) and within-subject coefficient of variation (wCV) were calculated for applicable metrics. RESULTS: Sixty-one participants were recruited. Inter-sonographer ICC was 0.86 (95% confidence interval: 0.77-0.92) for AC and 0.87 (0.78-0.92) for log-transformed BSC (logBSC = 10log10BSC) using one acquisition per sonographer. ICC was 0.88 (0.80-0.93) for both AC and logBSC averaging 5 acquisitions. ICC for SWS was 0.57 (0.29-0.74) using one acquisition per sonographer, and 0.84 (0.66-0.93) using 10 acquisitions. The wCV was ~7% for AC, and 19-43% for SWS, depending on number of acquisitions. CONCLUSIONS: Hepatic AC, BSC and SWS measures on a clinical scanner have good inter-sonographer reproducibility in adults with known or suspected NAFLD. Multiple acquisitions are required for SWS but not AC or BSC to achieve good inter-sonographer reproducibility. KEY POINTS: • AC, BSC and SWS measurements are reproducible in adults with NAFLD. • Inter-sonographer reproducibility of SWS measurement improves with more acquisitions being averaged. • Multiple acquisitions are required for SWS but not AC or BSC.
Authors: Jeremy S Paige; Gregory S Bernstein; Elhamy Heba; Eduardo A C Costa; Marilia Fereirra; Tanya Wolfson; Anthony C Gamst; Mark A Valasek; Grace Y Lin; Aiguo Han; John W Erdman; William D O'Brien; Michael P Andre; Rohit Loomba; Claude B Sirlin Journal: AJR Am J Roentgenol Date: 2017-03-07 Impact factor: 3.959
Authors: Aiguo Han; Michael P Andre; John W Erdman; Rohit Loomba; Claude B Sirlin; William D O'Brien Journal: IEEE Trans Ultrason Ferroelectr Freq Control Date: 2016-07-09 Impact factor: 2.725
Authors: Mark L Palmeri; Michael H Wang; Ned C Rouze; Manal F Abdelmalek; Cynthia D Guy; Barry Moser; Anna Mae Diehl; Kathryn R Nightingale Journal: J Hepatol Date: 2011-01-21 Impact factor: 25.083
Authors: Aiguo Han; Michael P Andre; Lisa Deiranieh; Elise Housman; John W Erdman; Rohit Loomba; Claude B Sirlin; William D O'Brien Journal: J Ultrasound Med Date: 2018-01-23 Impact factor: 2.153
Authors: Giovanna Ferraioli; Carlo Filice; Laurent Castera; Byung Ihn Choi; Ioan Sporea; Stephanie R Wilson; David Cosgrove; Christoph F Dietrich; Dominique Amy; Jeffrey C Bamber; Richard Barr; Yi-Hong Chou; Hong Ding; Andre Farrokh; Mireen Friedrich-Rust; Timothy J Hall; Kazutaka Nakashima; Kathryn R Nightingale; Mark L Palmeri; Fritz Schafer; Tsuyoshi Shiina; Shinichi Suzuki; Masatoshi Kudo Journal: Ultrasound Med Biol Date: 2015-03-20 Impact factor: 2.998
Authors: David E Kleiner; Elizabeth M Brunt; Mark Van Natta; Cynthia Behling; Melissa J Contos; Oscar W Cummings; Linda D Ferrell; Yao-Chang Liu; Michael S Torbenson; Aynur Unalp-Arida; Matthew Yeh; Arthur J McCullough; Arun J Sanyal Journal: Hepatology Date: 2005-06 Impact factor: 17.425
Authors: Barbara L McFarlin; Viksit Kumar; Timothy A Bigelow; Douglas G Simpson; Rosemary C White-Traut; Jacques S Abramowicz; William D O'Brien Journal: Ultrasound Med Biol Date: 2015-08-08 Impact factor: 2.998
Authors: Aiguo Han; Yingzhen N Zhang; Andrew S Boehringer; Vivian Montes; Michael P Andre; John W Erdman; Rohit Loomba; Mark A Valasek; Claude B Sirlin; William D O'Brien Journal: Radiology Date: 2020-02-04 Impact factor: 11.105
Authors: Joe L Rowles; Aiguo Han; Rita J Miller; Jamie R Kelly; Catherine C Applegate; Matthew A Wallig; William D O'Brien; John W Erdman Journal: Nutr Res Date: 2018-12-14 Impact factor: 3.315
Authors: Aiguo Han; Yingzhen N Zhang; Andrew S Boehringer; Michael P Andre; John W Erdman; Rohit Loomba; Claude B Sirlin; William D O'Brien Journal: Eur Radiol Date: 2019-02-19 Impact factor: 5.315
Authors: Shi Chen; Barbara L McFarlin; Barbara T Meagher; Tara A Peters; Douglas G Simpson; William D O'Brien; Aiguo Han Journal: IEEE Trans Ultrason Ferroelectr Freq Control Date: 2019-06-14 Impact factor: 2.725
Authors: Jinho Jung; Aiguo Han; Egbert Madamba; Ricki Bettencourt; Rohan R Loomba; Andrew S Boehringer; Michael P Andre; John W Erdman; William D O'Brien; Kathryn J Fowler; Claude B Sirlin; Rohit Loomba Journal: Radiology Date: 2022-03-29 Impact factor: 29.146
Authors: Yingzhen N Zhang; Kathryn J Fowler; Arinc Ozturk; Chetan K Potu; Ashley L Louie; Vivian Montes; Walter C Henderson; Kang Wang; Michael P Andre; Anthony E Samir; Claude B Sirlin Journal: J Magn Reson Imaging Date: 2019-03-12 Impact factor: 4.813
Authors: Aiguo Han; Michal Byra; Elhamy Heba; Michael P Andre; John W Erdman; Rohit Loomba; Claude B Sirlin; William D O'Brien Journal: Radiology Date: 2020-02-25 Impact factor: 29.146