Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Epigenetic Priming in Cancer Initiation.

Literature DB >> 29860985

Epigenetic Priming in Cancer Initiation.

Carolina Vicente-Dueñas¹, Julia Hauer², César Cobaleda³, Arndt Borkhardt⁴, Isidro Sánchez-García⁵.

Abstract

Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance. Epigenetic priming may remain latent until it is later triggered by endogenous or environmental stimuli. This Opinion article addresses the impact of epigenetic priming in cancer development and in the design of new therapeutic approaches.

Entities: Disease

Keywords: cancer; cancer stem cell; cancer therapy; oncogenes; reprogramming; stem cells

Mesh：

Year: 2018 PMID： 29860985 DOI： 10.1016/j.trecan.2018.04.007

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

Keyword Cloud
Cited

34 in total

1. Lineage choice decisions in B-cell development and leukemia.

Authors: Javier Raboso-Gallego; Ana Casado-García; Guillermo Rodríguez-Hernández; Carolina Vicente-Dueñas; Isidro Sánchez-García
Journal: Stem Cell Investig Date: 2018-12-07

Review 2. Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis.

Authors: Zhishan Wang; Chengfeng Yang
Journal: Semin Cancer Biol Date: 2019-01-11 Impact factor: 15.707

3. T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology.

Authors: Guillermo Rodríguez-Hernández; Sanil Bhatia; Carolina Vicente-Dueñas; Arndt Borkhardt; Julia Hauer; Isidro Sánchez-García
Journal: Mol Cell Oncol Date: 2018-08-07

4. Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2.

Authors: Amel Dudakovic; Rebekah M Samsonraj; Christopher R Paradise; Catalina Galeano-Garces; Merel O Mol; Daniela Galeano-Garces; Pengfei Zan; M Lizeth Galvan; Mario Hevesi; Oksana Pichurin; Roman Thaler; Dana L Begun; Peter Kloen; Marcel Karperien; A Noelle Larson; Jennifer J Westendorf; Simon M Cool; Andre J van Wijnen
Journal: J Biol Chem Date: 2020-04-24 Impact factor: 5.157

Review 5. Epigenetically distinct sister chromatids and asymmetric generation of tumor initiating cells.

Authors: Yongqing Liu; Laura Siles; Antonio Postigo; Douglas C Dean
Journal: Cell Cycle Date: 2018-10-13 Impact factor: 4.534

6. Preclinical assessment of histone deacetylase inhibitor quisinostat as a therapeutic agent against esophageal squamous cell carcinoma.

Authors: Lei Zhong; Shu Zhou; Rongsheng Tong; Jianyou Shi; Lan Bai; Yuxuan Zhu; Xingmei Duan; Wenzhao Liu; Jinku Bao; Lingyu Su; Qian Peng
Journal: Invest New Drugs Date: 2018-08-31 Impact factor: 3.850

7. Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas.

Authors: Lora H Ellenson; Britta Weigelt; Robert A Soslow; Amir Momeni-Boroujeni; Wissam Dahoud; Chad M Vanderbilt; Sarah Chiang; Rajmohan Murali; Eric V Rios-Doria; Kaled M Alektiar; Carol Aghajanian; Nadeem R Abu-Rustum; Marc Ladanyi
Journal: Clin Cancer Res Date: 2021-02-18 Impact factor: 12.531