Literature DB >> 33392513

Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and Leukemia.

Ute Fischer1, Jun J Yang2, Tomokatsu Ikawa3, Daniel Hein4, Carolina Vicente-Dueñas5, Arndt Borkhardt4, Isidro Sánchez-García6,7.   

Abstract

B-cells are an integral part of the adaptive immune system and regulate innate immunity. Derived from hematopoietic stem cells they mature through a series of cell fate decisions. Complex transcriptional circuits form and dissipate dynamically during these lineage restrictions. Genomic aberrations of involved transcription factors underlie various B-cell disorders. Acquired somatic aberrations are associated with cancer, whereas germline variations predispose to both malignant and non-malignant diseases. We review the opposing role of transcription factors during B-cell development in health and disease. We focus on early B-cell leukemia and discuss novel causative gene-environment cooperations and their implications for precision medicine.

Entities:  

Keywords:  B-cell; Transcription factors; childhood leukemia; environment; germline; mouse models; somatic

Mesh：

Substances：

Year:  2020        PMID： 33392513      PMCID： PMC7774874          DOI： 10.1158/2643-3230.BCD-20-0011

Source DB:  PubMed          Journal:  Blood Cancer Discov        ISSN： 2643-3230


  75 in total

1.  Early hematopoietic lineage restrictions directed by Ikaros.

Authors:  Toshimi Yoshida; Samuel Yao-Ming Ng; Juan Carlos Zuniga-Pflucker; Katia Georgopoulos
Journal:  Nat Immunol       Date:  2006-03-05       Impact factor: 25.606

Review 2.  Models of haematopoiesis: seeing the wood for the trees.

Authors:  Rhodri Ceredig; Antonius G Rolink; Geoffrey Brown
Journal:  Nat Rev Immunol       Date:  2009-04       Impact factor: 53.106

Review 3.  Somatic and germline genomics in paediatric acute lymphoblastic leukaemia.

Authors:  Ching-Hon Pui; Kim E Nichols; Jun J Yang
Journal:  Nat Rev Clin Oncol       Date:  2019-04       Impact factor: 66.675

4.  Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia.

Authors:  Meriem Ben-Ali; Jing Yang; Koon Wing Chan; Imen Ben-Mustapha; Najla Mekki; Chaouki Benabdesselem; Fethi Mellouli; Mohamed Bejaoui; Wanling Yang; Lamia Aissaoui; Yu Lung Lau; Mohamed-Ridha Barbouche
Journal:  J Allergy Clin Immunol       Date:  2017-05-19       Impact factor: 10.793

5.  Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening.

Authors:  Daniel Schäfer; Marianne Olsen; David Lähnemann; Martin Stanulla; Robert Slany; Kjeld Schmiegelow; Arndt Borkhardt; Ute Fischer
Journal:  Blood       Date:  2018-01-08       Impact factor: 22.113

6.  Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins.

Authors:  A T Maia; V H J van der Velden; C J Harrison; T Szczepanski; M D Williams; M J Griffiths; J J M van Dongen; M F Greaves
Journal:  Leukemia       Date:  2003-11       Impact factor: 11.528

7.  Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.

Authors:  Charles G Mullighan; Xiaoping Su; Jinghui Zhang; Ina Radtke; Letha A A Phillips; Christopher B Miller; Jing Ma; Wei Liu; Cheng Cheng; Brenda A Schulman; Richard C Harvey; I-Ming Chen; Robert J Clifford; William L Carroll; Gregory Reaman; W Paul Bowman; Meenakshi Devidas; Daniela S Gerhard; Wenjian Yang; Mary V Relling; Sheila A Shurtleff; Dario Campana; Michael J Borowitz; Ching-Hon Pui; Malcolm Smith; Stephen P Hunger; Cheryl L Willman; James R Downing
Journal:  N Engl J Med       Date:  2009-01-07       Impact factor: 91.245

8.  Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.

Authors:  Takaya Moriyama; Monika L Metzger; Gang Wu; Rina Nishii; Maoxiang Qian; Meenakshi Devidas; Wenjian Yang; Cheng Cheng; Xueyuan Cao; Emily Quinn; Susana Raimondi; Julie M Gastier-Foster; Elizabeth Raetz; Eric Larsen; Paul L Martin; W Paul Bowman; Naomi Winick; Yoshihiro Komada; Shuoguo Wang; Michael Edmonson; Heng Xu; Elaine Mardis; Robert Fulton; Ching-Hon Pui; Charles Mullighan; William E Evans; Jinghui Zhang; Stephen P Hunger; Mary V Relling; Kim E Nichols; Mignon L Loh; Jun J Yang
Journal:  Lancet Oncol       Date:  2015-10-28       Impact factor: 41.316

9.  Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

Authors:  Grace J Liu; Luisa Cimmino; Julian G Jude; Yifang Hu; Matthew T Witkowski; Mark D McKenzie; Mutlu Kartal-Kaess; Sarah A Best; Laura Tuohey; Yang Liao; Wei Shi; Charles G Mullighan; Michael A Farrar; Stephen L Nutt; Gordon K Smyth; Johannes Zuber; Ross A Dickins
Journal:  Genes Dev       Date:  2014-06-15       Impact factor: 11.361

10.  Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

Authors:  Xiaotu Ma; Yu Liu; Yanling Liu; Ludmil B Alexandrov; Michael N Edmonson; Charles Gawad; Xin Zhou; Yongjin Li; Michael C Rusch; John Easton; Robert Huether; Veronica Gonzalez-Pena; Mark R Wilkinson; Leandro C Hermida; Sean Davis; Edgar Sioson; Stanley Pounds; Xueyuan Cao; Rhonda E Ries; Zhaoming Wang; Xiang Chen; Li Dong; Sharon J Diskin; Malcolm A Smith; Jaime M Guidry Auvil; Paul S Meltzer; Ching C Lau; Elizabeth J Perlman; John M Maris; Soheil Meshinchi; Stephen P Hunger; Daniela S Gerhard; Jinghui Zhang
Journal:  Nature       Date:  2018-02-28       Impact factor: 49.962
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  9 in total

Review 1.  Linear and Circular Long Non-Coding RNAs in Acute Lymphoblastic Leukemia: From Pathogenesis to Classification and Treatment.

Authors:  Yasen Maimaitiyiming; Linyan Ye; Tao Yang; Wenjuan Yu; Hua Naranmandura
Journal:  Int J Mol Sci       Date:  2022-04-18       Impact factor: 6.208

Review 2.  Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia.

Authors:  Cesar Cobaleda; Carolina Vicente-Dueñas; Isidro Sanchez-Garcia
Journal:  Nat Rev Immunol       Date:  2021-02-08       Impact factor: 53.106

Review 3.  Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging.

Authors:  Suzanne M Watt; Peng Hua; Irene Roberts
Journal:  Int J Mol Sci       Date:  2022-03-27       Impact factor: 5.923

4.  Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia.

Authors:  Stefan Nagel; Corinna Meyer
Journal:  Int J Mol Sci       Date:  2022-10-06       Impact factor: 6.208

Review 5.  Review of guidelines for the identification and clinical care of patients with genetic predisposition for hematological malignancies.

Authors:  Brigitte Schlegelberger; Cristina Mecucci; Marcin Wlodarski
Journal:  Fam Cancer       Date:  2021-05-31       Impact factor: 2.375

Review 6.  Regulatory Non-Coding RNAs Modulate Transcriptional Activation During B Cell Development.

Authors:  Mary Attaway; Tzippora Chwat-Edelstein; Bao Q Vuong
Journal:  Front Genet       Date:  2021-10-14       Impact factor: 4.599

7.  Toward prevention of childhood ALL by early-life immune training.

Authors:  Julia Hauer; Ute Fischer; Arndt Borkhardt
Journal:  Blood       Date:  2021-10-21       Impact factor: 22.113

8.  An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia.

Authors:  Ifat Geron; Angela Maria Savino; Hila Fishman; Noa Tal; John Brown; Virginia A Turati; Chela James; Jolanda Sarno; Michal Hameiri-Grossman; Yu Nee Lee; Avigail Rein; Hillary Maniriho; Yehudit Birger; Anna Zemlyansky; Inna Muler; Kara L Davis; Victoria Marcu-Malina; Nicole Mattson; Oren Parnas; Rabea Wagener; Ute Fischer; João T Barata; Catriona H M Jamieson; Markus Müschen; Chun-Wei Chen; Arndt Borkhardt; Ilan Richard Kirsch; Arnon Nagler; Tariq Enver; Shai Izraeli
Journal:  Nat Commun       Date:  2022-02-03       Impact factor: 17.694

Review 9.  Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia.

Authors:  Wenjuan Liao; M Eric Kohler; Terry Fry; Patricia Ernst
Journal:  Exp Hematol       Date:  2021-07-21       Impact factor: 3.084
  9 in total

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