Literature DB >> 30250933

T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology.

Guillermo Rodríguez-Hernández1,2, Sanil Bhatia3, Carolina Vicente-Dueñas2, Arndt Borkhardt3, Julia Hauer3, Isidro Sánchez-García1,2.   

Abstract

Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype. This approach allowed to identify that secondary genomic alterations, like Notch1 mutations, appeared late and only took place within the thymus during T-ALL development. These concepts are therefore critical for the development of modern therapies aimed at curing T-ALL.

Entities:  

Keywords:  Lmo2; Notch1; cancer; cancer cell-of-origin; cancer-stem-cell and tumor reprogramming; mouse models; stem cells; target cell

Year:  2018        PMID： 30250933      PMCID： PMC6150050          DOI： 10.1080/23723556.2018.1497860

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases.

Authors:  Guillermo Rodríguez-Hernández; Julia Hauer; Alberto Martín-Lorenzo; Daniel Schäfer; Christoph Bartenhagen; Idoia García-Ramírez; Franziska Auer; Inés González-Herrero; Lucia Ruiz-Roca; Michael Gombert; Vera Okpanyi; Ute Fischer; Cai Chen; Martin Dugas; Sanil Bhatia; René Martin Linka; Marta Garcia-Suquia; María Victoria Rascón-Trincado; Angel Garcia-Sanchez; Oscar Blanco; Maria Begoña García-Cenador; Francisco Javier García-Criado; César Cobaleda; Diego Alonso-López; Javier De Las Rivas; Markus Müschen; Carolina Vicente-Dueñas; Isidro Sánchez-García; Arndt Borkhardt
Journal:  Cancer Res       Date:  2017-06-19       Impact factor: 12.701

2.  The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia.

Authors:  Pieter Van Vlierberghe; Martine van Grotel; H Berna Beverloo; Charles Lee; Tryggvi Helgason; Jessica Buijs-Gladdines; Monique Passier; Elisabeth R van Wering; Anjo J P Veerman; Willem A Kamps; Jules P P Meijerink; Rob Pieters
Journal:  Blood       Date:  2006-07-27       Impact factor: 22.113

3.  Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.

Authors:  Jonah Riddell; Roi Gazit; Brian S Garrison; Guoji Guo; Assieh Saadatpour; Pankaj K Mandal; Wataru Ebina; Pavel Volchkov; Guo-Cheng Yuan; Stuart H Orkin; Derrick J Rossi
Journal:  Cell       Date:  2014-04-24       Impact factor: 41.582

4.  Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL.

Authors:  Alberto Martín-Lorenzo; Franziska Auer; Lai N Chan; Idoia García-Ramírez; Inés González-Herrero; Guillermo Rodríguez-Hernández; Christoph Bartenhagen; Martin Dugas; Michael Gombert; Sebastian Ginzel; Oscar Blanco; Alberto Orfao; Diego Alonso-López; Javier De Las Rivas; Maria B García-Cenador; Francisco J García-Criado; Markus Müschen; Isidro Sánchez-García; Arndt Borkhardt; Carolina Vicente-Dueñas; Julia Hauer
Journal:  Cancer Res       Date:  2018-02-28       Impact factor: 12.701

5.  Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice.

Authors:  Carolina Vicente-Dueñas; Lorena Fontán; Ines Gonzalez-Herrero; Isabel Romero-Camarero; Victor Segura; M Angela Aznar; Esther Alonso-Escudero; Elena Campos-Sanchez; Lucía Ruiz-Roca; Marcos Barajas-Diego; Ainara Sagardoy; Jose I Martinez-Ferrandis; Fernando Abollo-Jimenez; Cristina Bertolo; Ivan Peñuelas; Francisco J Garcia-Criado; María B García-Cenador; Thomas Tousseyn; Xabier Agirre; Felipe Prosper; Federico Garcia-Bragado; Ellen D McPhail; Izidore S Lossos; Ming-Qing Du; Teresa Flores; Jesus M Hernandez-Rivas; Marcos Gonzalez; Antonio Salar; Beatriz Bellosillo; Eulogio Conde; Reiner Siebert; Xavier Sagaert; Cesar Cobaleda; Isidro Sanchez-Garcia; Jose A Martinez-Climent
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-11       Impact factor: 11.205

Review 6.  Epigenetic Priming in Cancer Initiation.

Authors:  Carolina Vicente-Dueñas; Julia Hauer; César Cobaleda; Arndt Borkhardt; Isidro Sánchez-García
Journal:  Trends Cancer       Date:  2018-06

7.  Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.

Authors:  Idoia García-Ramírez; Sanil Bhatia; Guillermo Rodríguez-Hernández; Inés González-Herrero; Carolin Walter; Sara González de Tena-Dávila; Salma Parvin; Oskar Haas; Wilhelm Woessmann; Martin Stanulla; Martin Schrappe; Martin Dugas; Yasodha Natkunam; Alberto Orfao; Verónica Domínguez; Belén Pintado; Oscar Blanco; Diego Alonso-López; Javier De Las Rivas; Alberto Martín-Lorenzo; Rafael Jiménez; Francisco Javier García Criado; María Begoña García Cenador; Izidore S Lossos; Carolina Vicente-Dueñas; Arndt Borkhardt; Julia Hauer; Isidro Sánchez-García
Journal:  EMBO J       Date:  2018-06-07       Impact factor: 11.598

8.  A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.

Authors:  Carolina Vicente-Dueñas; Isabel Romero-Camarero; Inés González-Herrero; Esther Alonso-Escudero; Fernando Abollo-Jiménez; Xiaoyu Jiang; Norma C Gutierrez; Alberto Orfao; Nieves Marín; Luisa María Villar; Ma Carmen Fernández Criado; Belén Pintado; Teresa Flores; Diego Alonso-López; Javier De Las Rivas; Rafael Jiménez; Francisco Javier García Criado; María Begoña García Cenador; Izidore S Lossos; César Cobaleda; Isidro Sánchez-García
Journal:  EMBO J       Date:  2012-08-17       Impact factor: 11.598

9.  The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

Authors:  Yu Liu; John Easton; Ying Shao; Jamie Maciaszek; Zhaoming Wang; Mark R Wilkinson; Kelly McCastlain; Michael Edmonson; Stanley B Pounds; Lei Shi; Xin Zhou; Xiaotu Ma; Edgar Sioson; Yongjin Li; Michael Rusch; Pankaj Gupta; Deqing Pei; Cheng Cheng; Malcolm A Smith; Jaime Guidry Auvil; Daniela S Gerhard; Mary V Relling; Naomi J Winick; Andrew J Carroll; Nyla A Heerema; Elizabeth Raetz; Meenakshi Devidas; Cheryl L Willman; Richard C Harvey; William L Carroll; Kimberly P Dunsmore; Stuart S Winter; Brent L Wood; Brian P Sorrentino; James R Downing; Mignon L Loh; Stephen P Hunger; Jinghui Zhang; Charles G Mullighan
Journal:  Nat Genet       Date:  2017-07-03       Impact factor: 38.330

10.  Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.

Authors:  Jolien De Bie; Sofie Demeyer; Llucia Alberti-Servera; Ellen Geerdens; Heidi Segers; Michaël Broux; Kim De Keersmaecker; Lucienne Michaux; Peter Vandenberghe; Thierry Voet; Nancy Boeckx; Anne Uyttebroeck; Jan Cools
Journal:  Leukemia       Date:  2018-04-18       Impact factor: 11.528
  10 in total
  1 in total

1.  Lineage choice decisions in B-cell development and leukemia.

Authors:  Javier Raboso-Gallego; Ana Casado-García; Guillermo Rodríguez-Hernández; Carolina Vicente-Dueñas; Isidro Sánchez-García
Journal:  Stem Cell Investig       Date:  2018-12-07
  1 in total

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