Nutrigenomics and personalized nutrition: science and concept.

Diet and genomes interact. Nutrition has the most important life-long environmental impact on human health. While nutrigenetics addresses how an individual's genetic makeup predisposes for dietary susceptibility, nutrigenomics asks how nutrition influences the expression of the genome. Nutrigenomics builds on the three omics disciplines transcriptomics, proteomics and metabolomics. They are a prerequisite for nutritional systems biology, the understanding of the interaction between food components and diet with cells, organs and the whole body. Personalized nutrition is a conceptual analog to personalized medicine. While there are food products available that address requirements or preferences of specific consumer groups, these products are based on empirical consumer science rather than on nutrigenomics and nutrigenetics. The latter two build the science foundation for understanding human variability in preferences, requirements and responses to diet, and may become the future tools for consumer assessment motivated by personalized nutritional counseling for health maintenance and disease prevention.