Literature DB >> 2977648

Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.

T Kawaguchi1, S Fukushima, Y Hayashi, M Nakano.   

Abstract

The chemical and enzymatic reactivity of 5-fluoro-2'-deoxyuridine prodrugs esterified at the 3' and 5' positions with several acyl groups has been investigated. The enzymatic reactivity was affected by the acyl structure, the site of esterification, and the number of esters in the prodrug molecule.

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Year:  1988        PMID： 2977648     DOI： 10.1023/a:1015972214747

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  7 in total

1.  Selective anticancer effects of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine, a lipophilic prodrug of 5-fluoro-2'-deoxyuridine, dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor.

Authors:  S Fukushima; T Kawaguchi; M Nishida; K Juni; Y Yamashita; M Takahashi; M Nakano
Journal:  Cancer Res       Date:  1987-04-01       Impact factor: 12.701

2.  Activity of esterase in the hydrolysis of 3',5'-diesters of 5-fluoro-2'-deoxyuridine in relation to the structure of the diester prodrugs.

Authors:  T Kawaguchi; Y Suzuki; Y Nakahara; N Nambu; T Nagai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1985-01       Impact factor: 1.645

3.  3',5'-diesters of 5-fluoro-2'-deoxyuridine: synthesis and biological activity.

Authors:  Y Nishizawa; J E Casida
Journal:  Biochem Pharmacol       Date:  1965-11       Impact factor: 5.858

4.  3',5'-Diesters of 5-fluoro-2'-deoxyuridine and thymidine: hydrolysis by esterases in human, mouse, and insect tissue.

Authors:  J E Casida; J L Engel; Y Nishizawa
Journal:  Biochem Pharmacol       Date:  1966-05       Impact factor: 5.858

5.  A pharmacokinetic analysis program (multi) for microcomputer.

Authors:  K Yamaoka; Y Tanigawara; T Nakagawa; T Uno
Journal:  J Pharmacobiodyn       Date:  1981-11

6.  Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.

Authors:  T Kawaguchi; M Saito; Y Suzuki; N Nambu; T Nagai
Journal:  Chem Pharm Bull (Tokyo)       Date:  1985-04       Impact factor: 1.645

7.  Antitumor activity of 3',5'-diesters of 5-fluoro-2'-deoxyuridine against murine leukemia L1210 cells.

Authors:  F Kanzawa; A Hoshi; K Kuretani; M Saneyoshi; T Kawaguchi
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333
  7 in total
  1 in total

1.  Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.

Authors:  Balvinder S Vig; Philip J Lorenzi; Sachin Mittal; Christopher P Landowski; Ho-Chul Shin; Henry I Mosberg; John M Hilfinger; Gordon L Amidon
Journal:  Pharm Res       Date:  2003-09       Impact factor: 4.200
  1 in total

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