Literature DB >> 7328489

A pharmacokinetic analysis program (multi) for microcomputer.

K Yamaoka, Y Tanigawara, T Nakagawa, T Uno.   

Abstract

A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

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Year:  1981        PMID： 7328489     DOI： 10.1248/bpb1978.4.879

Source DB:  PubMed          Journal:  J Pharmacobiodyn        ISSN： 0386-846X


  340 in total

1.  Some pharmacokinetic parameters of eprinomectin in goats following pour-on administration.

Authors:  M Alvinerie; E Lacoste; J F Sutra; C Chartier
Journal:  Vet Res Commun       Date:  1999-11       Impact factor: 2.459

2.  Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model.

Authors:  H Takanaga; A Ohnishi; H Matsuo; H Murakami; H Sata; K Kuroda; A Urae; S Higuchi; Y Sawada
Journal:  Br J Clin Pharmacol       Date:  2000-01       Impact factor: 4.335

3.  Analysis of nonlinear and nonsteady state hepatic extraction with the dispersion model using the finite difference method.

Authors:  A Hisaka; Y Sugiyama
Journal:  J Pharmacokinet Biopharm       Date:  1998-10

4.  Some pharmacokinetic parameters and dosage regimens for a long-acting formulation of oxytetracycline in 6- to 8-month-old male calves.

Authors:  R Kumar; J K Malik
Journal:  Vet Res Commun       Date:  1998-12       Impact factor: 2.459

5.  Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4.

Authors:  S Kanamitsu; K Ito; C E Green; C A Tyson; N Shimada; Y Sugiyama
Journal:  Pharm Res       Date:  2000-04       Impact factor: 4.200

6.  Quantitative evaluation of capacity-limited hepatobiliary transport based on hepatocellular diffusion model by MULTI(FEM).

Authors:  M Higashimori; K Yamaoka; S Fujitani; T Nakagawa
Journal:  J Pharmacokinet Pharmacodyn       Date:  2001-10       Impact factor: 2.745

7.  Carrier-mediated transport of macrolide antimicrobial agents across Caco-2 cell monolayers.

Authors:  H Saito; Y Fukasawa; Y Otsubo; K Yamada; H Sezaki; S Yamashita
Journal:  Pharm Res       Date:  2000-06       Impact factor: 4.200

8.  Pharmacokinetic analysis of benzodiazepine receptor binding of [123I]iomazenil in human brain.

Authors:  K Ito; T Momose; H Kotaki; Y Kojima; K Yamamoto; M Katashima; Y Sawada; Y Sasaki; T Iga
Journal:  Pharm Res       Date:  1997-08       Impact factor: 4.200

9.  In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system.

Authors:  H Kita; H Matsuo; H Takanaga; J Kawakami; K Yamamoto; T Iga; M Naito; T Tsuruo; A Asanuma; K Yanagisawa; Y Sawada
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

10.  Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1.

Authors:  Atsuko Okamura; Akiko Emoto; Noriko Koyabu; Hisakazu Ohtani; Yasufumi Sawada
Journal:  Br J Pharmacol       Date:  2002-10       Impact factor: 8.739
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