Literature DB >> 2931191

Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.

T Kawaguchi, M Saito, Y Suzuki, N Nambu, T Nagai.   

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Year:  1985        PMID： 2931191     DOI： 10.1248/cpb.33.1652

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


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  7 in total

1.  Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.

Authors:  T Kawaguchi; S Fukushima; Y Hayashi; M Nakano
Journal:  Pharm Res       Date:  1988-11       Impact factor: 4.200

2.  Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.

Authors:  Christopher P Landowski; Xueqin Song; Philip L Lorenzi; John M Hilfinger; Gordon L Amidon
Journal:  Pharm Res       Date:  2005-08-24       Impact factor: 4.200

3.  The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability.

Authors:  Yasuhiro Tsume; Tuba Incecayir; Xueqin Song; John M Hilfinger; Gordon L Amidon
Journal:  Eur J Pharm Biopharm       Date:  2013-12-19       Impact factor: 5.571

4.  Synthesis and in vitro evaluation of bile acid prodrugs of floxuridine to target the liver.

Authors:  Diana Vivian; James E Polli
Journal:  Int J Pharm       Date:  2014-09-16       Impact factor: 5.875

Review 5.  Role of solute carriers in response to anticancer drugs.

Authors:  Qing Li; Yan Shu
Journal:  Mol Cell Ther       Date:  2014-05-27

6.  Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.

Authors:  Yasuhiro Tsume; John M Hilfinger; Gordon L Amidon
Journal:  Mol Pharm       Date:  2008-07-25       Impact factor: 4.939

7.  The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs.

Authors:  Yasuhiro Tsume; Blanca Borras Bermejo; Gordon L Amidon
Journal:  Pharmaceuticals (Basel)       Date:  2014-01-27
  7 in total

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