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Literature DB >> 6194440

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

C Montell, E F Fisher, M H Caruthers, A J Berk.

Abstract

A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylation but is required for the cleavage step preceding polyadenylation to occur efficiently.

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Year: 1983 PMID： 6194440 DOI： 10.1038/305600a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

116 in total

1. Two distant upstream regions containing cis-acting signals regulating splicing facilitate 3'-end processing of avian sarcoma virus RNA.

Authors: J T Miller; C M Stoltzfus
Journal: J Virol Date: 1992-07 Impact factor: 5.103

2. Differential utilization of poly (A) signals between DHFR alleles in CHL cells.

Authors: K W Scotto; H Yang; J P Davide; P W Melera
Journal: Nucleic Acids Res Date: 1992-12-25 Impact factor: 16.971

3. Readthrough activation of early adenovirus E1b gene transcription.

Authors: L F Maxfield; D J Spector
Journal: J Virol Date: 1997-11 Impact factor: 5.103

4. Molecular structure of Tcp-10 genes from the t complex responder locus.

Authors: D C Bullard; J C Schimenti
Journal: Mamm Genome Date: 1991 Impact factor: 2.957

5. Isolation of a complementary DNA encoding the bean PR4 chitinase: an acidic enzyme with an amino-terminus cysteine-rich domain.

Authors: M Margis-Pinheiro; M H Metz-Boutigue; A Awade; M de Tapia; M le Ret; G Burkard
Journal: Plant Mol Biol Date: 1991-08 Impact factor: 4.076

6. Structure and expression of a gene encoding a putative GTP-binding protein identified by provirus integration in a transgenic mouse strain.

Authors: K Mooslehner; U Müller; U Karls; L Hamann; K Harbers
Journal: Mol Cell Biol Date: 1991-02 Impact factor: 4.272

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

1. Two distant upstream regions containing cis-acting signals regulating splicing facilitate 3'-end processing of avian sarcoma virus RNA.

2. Differential utilization of poly (A) signals between DHFR alleles in CHL cells.

3. Readthrough activation of early adenovirus E1b gene transcription.

4. Molecular structure of Tcp-10 genes from the t complex responder locus.

5. Isolation of a complementary DNA encoding the bean PR4 chitinase: an acidic enzyme with an amino-terminus cysteine-rich domain.

6. Structure and expression of a gene encoding a putative GTP-binding protein identified by provirus integration in a transgenic mouse strain.

7. Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus.

8. Plant cells do not properly recognize animal gene polyadenylation signals.

9. Copper metallothionein of yeast, structure of the gene, and regulation of expression.

10. Sequences responsible for transcription termination on a gene segment in Saccharomyces cerevisiae.