Literature DB >> 29767190

Aggregation kinetics of the Aβ1-40 peptide monitored by NMR.

Giovanni Bellomo1, Sara Bologna1, Leonardo Gonnelli1, Enrico Ravera2, Marco Fragai2, Moreno Lelli2, Claudio Luchinat3.   

Abstract

The aggregation of Aβ1-40 was monitored by solution NMR, which showed a trend complementary to the one observed by ThT-fluorescence. The NMR data support a kinetic model where Aβ1-40 initially aggregates with the reversible formation of oligomeric species, which then irreversibly convert into fibrils.

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Year:  2018        PMID： 29767190     DOI： 10.1039/c8cc01710g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

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Authors:  Bikash R Sahoo; Sarah J Cox; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2020-04-17       Impact factor: 6.222

2.  Probing transient non-native states in amyloid beta fiber elongation by NMR.

Authors:  Jeffrey R Brender; Anirban Ghosh; Samuel A Kotler; Janarthanan Krishnamoorthy; Swapna Bera; Vanessa Morris; Timir Baran Sil; Kanchan Garai; Bernd Reif; Anirban Bhunia; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2019-04-11       Impact factor: 6.222

3.  Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer's Amyloid Beta.

Authors:  Yunxiang Sun; Aleksandr Kakinen; Xulin Wan; Niamh Moriarty; Cameron P J Hunt; Yuhuan Li; Nicholas Andrikopoulos; Aparna Nandakumar; Thomas P Davis; Clare L Parish; Yang Song; Pu Chun Ke; Feng Ding
Journal:  Nano Today       Date:  2021-03-13       Impact factor: 18.962

4.  Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation.

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Journal:  J Phys Chem Lett       Date:  2019-06-06       Impact factor: 6.475

Review 5.  An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

Authors:  Miriam Sciaccaluga; Alfredo Megaro; Giovanni Bellomo; Gabriele Ruffolo; Michele Romoli; Eleonora Palma; Cinzia Costa
Journal:  Int J Mol Sci       Date:  2021-06-01       Impact factor: 5.923

6.  Measurement of CSF core Alzheimer disease biomarkers for routine clinical diagnosis: do fresh vs frozen samples differ?

Authors:  Giovanni Bellomo; Samuela Cataldi; Silvia Paciotti; Federico Paolini Paoletti; Davide Chiasserini; Lucilla Parnetti
Journal:  Alzheimers Res Ther       Date:  2020-09-29       Impact factor: 6.982

7.  Identification of on- and off-pathway oligomers in amyloid fibril formation.

Authors:  Alexander J Dear; Georg Meisl; Anđela Šarić; Thomas C T Michaels; Magnus Kjaergaard; Sara Linse; Tuomas P J Knowles
Journal:  Chem Sci       Date:  2020-06-08       Impact factor: 9.825

8.  Slow Dissolution Kinetics of Model Peptide Fibrils.

Authors:  Mona Koder Hamid; Axel Rüter; Stefan Kuczera; Ulf Olsson
Journal:  Int J Mol Sci       Date:  2020-10-16       Impact factor: 5.923

9.  Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by 1H NMR and All-Atom Molecular Dynamics Simulations.

Authors:  Johanna Hjalte; Shakhawath Hossain; Andreas Hugerth; Helen Sjögren; Marie Wahlgren; Per Larsson; Dan Lundberg
Journal:  Mol Pharm       Date:  2022-02-01       Impact factor: 4.939
  9 in total

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