Literature DB >> 30917192

Probing transient non-native states in amyloid beta fiber elongation by NMR.

Jeffrey R Brender1, Anirban Ghosh, Samuel A Kotler, Janarthanan Krishnamoorthy, Swapna Bera, Vanessa Morris, Timir Baran Sil, Kanchan Garai, Bernd Reif, Anirban Bhunia, Ayyalusamy Ramamoorthy.   

Abstract

Using NMR to probe transient binding of Aβ1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 30917192      PMCID： PMC6544147          DOI： 10.1039/c9cc01067j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

1.  Kinetic analysis of beta-amyloid fibril elongation.

Authors:  Michelle J Cannon; Angela D Williams; Ronald Wetzel; David G Myszka
Journal:  Anal Biochem       Date:  2004-05-01       Impact factor: 3.365

Review 2.  Toward a molecular theory of early and late events in monomer to amyloid fibril formation.

Authors:  John E Straub; D Thirumalai
Journal:  Annu Rev Phys Chem       Date:  2011       Impact factor: 12.703

3.  Thermodynamics of A beta(1-40) amyloid fibril elongation.

Authors:  Brian O'Nuallain; Shankaramma Shivaprasad; Indu Kheterpal; Ronald Wetzel
Journal:  Biochemistry       Date:  2005-09-27       Impact factor: 3.162

4.  Elongation dynamics of amyloid fibrils: a rugged energy landscape picture.

Authors:  Chiu Fan Lee; James Loken; Létitia Jean; David J Vaux
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2009-10-06

5.  Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy.

Authors:  Yuichi Yoshimura; Kazumasa Sakurai; Young-Ho Lee; Takahisa Ikegami; Eri Chatani; Hironobu Naiki; Yuji Goto
Journal:  Protein Sci       Date:  2010-11-11       Impact factor: 6.725

6.  Solid-state NMR spectroscopic investigation of Aβ protofibrils: implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils.

Authors:  Holger A Scheidt; Isabel Morgado; Sven Rothemund; Daniel Huster; Marcus Fändrich
Journal:  Angew Chem Int Ed Engl       Date:  2011-02-14       Impact factor: 15.336

7.  Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation.

Authors:  Nicolas L Fawzi; Jinfa Ying; Dennis A Torchia; G Marius Clore
Journal:  J Am Chem Soc       Date:  2010-07-28       Impact factor: 15.419

8.  Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.

Authors:  Sourajit M Mustafi; Kanchan Garai; Scott L Crick; Berevan Baban; Carl Frieden
Journal:  Biochem Biophys Res Commun       Date:  2010-05-31       Impact factor: 3.575

9.  Quartz crystal microbalance analysis of growth kinetics for aggregation intermediates of the amyloid-beta protein.

Authors:  Joseph A Kotarek; Kathryn C Johnson; Melissa A Moss
Journal:  Anal Biochem       Date:  2008-03-16       Impact factor: 3.365

10.  Abeta protofibrils possess a stable core structure resistant to hydrogen exchange.

Authors:  Indu Kheterpal; Hilal A Lashuel; Dean M Hartley; Thomas Walz; Peter T Lansbury; Ronald Wetzel
Journal:  Biochemistry       Date:  2003-12-09       Impact factor: 3.162
View more
  13 in total

1.  N-Terminal Modified Aβ Variants Enable Modulations to the Structures and Cytotoxicity Levels of Wild-Type Aβ Fibrils through Cross-Seeding.

Authors:  Zhi-Wen Hu; Dan Fai Au; Letticia Cruceta; Liliya Vugmeyster; Wei Qiang
Journal:  ACS Chem Neurosci       Date:  2020-07-06       Impact factor: 4.418

Review 2.  High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease.

Authors:  Bikash R Sahoo; Sarah J Cox; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2020-04-17       Impact factor: 6.222

3.  Acetylation of Aβ42 at Lysine 16 Disrupts Amyloid Formation.

Authors:  Rashmi Adhikari; Mu Yang; Nabanita Saikia; Colina Dutta; Wafa F A Alharbi; Zhiying Shan; Ravindra Pandey; Ashutosh Tiwari
Journal:  ACS Chem Neurosci       Date:  2020-04-02       Impact factor: 4.418

4.  Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta.

Authors:  Huayuan Tang; Yuhuan Li; Aleksandr Kakinen; Nicholas Andrikopoulos; Yunxiang Sun; Eunbi Kwak; Thomas P Davis; Feng Ding; Pu Chun Ke
Journal:  Phys Chem Chem Phys       Date:  2021-12-22       Impact factor: 3.676

Review 5.  High-Speed Atomic Force Microscopy Reveals the Structural Dynamics of the Amyloid-β and Amylin Aggregation Pathways.

Authors:  Takahiro Watanabe-Nakayama; Bikash R Sahoo; Ayyalusamy Ramamoorthy; Kenjiro Ono
Journal:  Int J Mol Sci       Date:  2020-06-16       Impact factor: 5.923

6.  DMPC Phospholipid Bilayer as a Potential Interface for Human Cystatin C Oligomerization: Analysis of Protein-Liposome Interactions Using NMR Spectroscopy.

Authors:  Przemyslaw Jurczak; Kosma Szutkowski; Slawomir Lach; Stefan Jurga; Paulina Czaplewska; Aneta Szymanska; Igor Zhukov
Journal:  Membranes (Basel)       Date:  2020-12-24

7.  Biophysical Investigation of the Interplay between the Conformational Species of Domain-Swapped GB1 Amyloid Mutant through Real-Time Monitoring of Amyloid Fibrillation.

Authors:  Renuka Ranjan; Nidhi Tiwari; Arvind M Kayastha; Neeraj Sinha
Journal:  ACS Omega       Date:  2021-12-07

8.  An explicitly designed paratope of amyloid-β prevents neuronal apoptosis in vitro and hippocampal damage in rat brain.

Authors:  Ashim Paul; Sourav Kumar; Sujan Kalita; Sourav Kalita; Dibakar Sarkar; Anirban Bhunia; Anupam Bandyopadhyay; Amal Chandra Mondal; Bhubaneswar Mandal
Journal:  Chem Sci       Date:  2020-12-22       Impact factor: 9.825

9.  Probing the Influence of Single-Site Mutations in the Central Cross-β Region of Amyloid β (1-40) Peptides.

Authors:  Jacob Fritzsch; Alexander Korn; Dayana Surendran; Martin Krueger; Holger A Scheidt; Kaustubh R Mote; Perunthiruthy K Madhu; Sudipta Maiti; Daniel Huster
Journal:  Biomolecules       Date:  2021-12-09

10.  Early Divergence in Misfolding Pathways of Amyloid-Beta Peptides.

Authors:  Salvatore Mamone; Stefan Glöggler; Stefan Becker; Nasrollah Rezaei-Ghaleh
Journal:  Chemphyschem       Date:  2021-08-19       Impact factor: 3.102
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.