Anja Müller-Lutz1, Alexandra Ljimani2, Julia Stabinska1, Moritz Zaiss3, Johannes Boos1, Hans-Jörg Wittsack1, Christoph Schleich1. 1. Department of Diagnostic and Interventional Radiology, University Dusseldorf Medical Faculty, 40225, Düsseldorf, Germany. 2. Department of Diagnostic and Interventional Radiology, University Dusseldorf Medical Faculty, 40225, Düsseldorf, Germany. Alexandra.Ljimani@med.uni-duesseldorf.de. 3. High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Abstract
PURPOSE: The study compares glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging of intervertebral discs corrected for solely B0 inhomogeneities or both B0 and B1 inhomogeneities. METHODS: Lumbar intervertebral discs of 20 volunteers were examined with T2-weighted and gagCEST imaging. Field inhomogeneity correction was performed with B0 correction only and with correction of both B0 and B1. GagCEST effects measured by the asymmetric magnetization transfer ratio (MTRasym) and signal-to-noise ratio (SNR) were compared between both methods. RESULTS: Significant higher MTRasym and SNR values were obtained in the nucleus pulposus using B0 and B1 correction compared with B0-corrected gagCEST. The GagCEST effect was significantly different in the nucleus pulposus compared with the annulus fibrosus for both methods. CONCLUSION: The B0 and B1 field inhomogeneity correction method leads to an improved quality of gagCEST imaging in IVDs compared with only B0 correction.
PURPOSE: The study compares glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging of intervertebral discs corrected for solely B0 inhomogeneities or both B0 and B1 inhomogeneities. METHODS: Lumbar intervertebral discs of 20 volunteers were examined with T2-weighted and gagCEST imaging. Field inhomogeneity correction was performed with B0 correction only and with correction of both B0 and B1. GagCEST effects measured by the asymmetric magnetization transfer ratio (MTRasym) and signal-to-noise ratio (SNR) were compared between both methods. RESULTS: Significant higher MTRasym and SNR values were obtained in the nucleus pulposus using B0 and B1 correction compared with B0-corrected gagCEST. The GagCEST effect was significantly different in the nucleus pulposus compared with the annulus fibrosus for both methods. CONCLUSION: The B0 and B1 field inhomogeneity correction method leads to an improved quality of gagCEST imaging in IVDs compared with only B0 correction.
Entities:
Keywords:
Chemical exchange saturation transfer; Field inhomogeneity correction; Glycosaminoglycans; Intervertebral disks; WASABI; WASSR
Authors: Patrick Schuenke; Johannes Windschuh; Volkert Roeloffs; Mark E Ladd; Peter Bachert; Moritz Zaiss Journal: Magn Reson Med Date: 2016-02-09 Impact factor: 4.668
Authors: Miriam Frenken; David Latz; Erik Schiffner; Wolfgang Alois Quante; Maxime Knautz; Daniel Benjamin Abrar; Benedikt Schaarschmidt; Christoph Schleich Journal: J Orthop Date: 2019-06-04
Authors: Karl Ludger Radke; Lena Marie Wilms; Miriam Frenken; Julia Stabinska; Marek Knet; Benedikt Kamp; Thomas Andreas Thiel; Timm Joachim Filler; Sven Nebelung; Gerald Antoch; Daniel Benjamin Abrar; Hans-Jörg Wittsack; Anja Müller-Lutz Journal: Int J Mol Sci Date: 2022-06-22 Impact factor: 6.208