OBJECTIVE: Effect of conservative therapy on intervertebral discs (IVD) in patients with leg-length-discrepancy (LLD). M&M: Seventy lumbar IVDs of 14 participants (five with LLD 10-20 mm) were examined using a 3T-MRI-scanner. Morphological (Pfirrmann) and molecular (glycosaminoglycan-chemical-exchange-saturation-transfer, gagCEST) grading was assessed before and after a four-month therapy (physiotherapy and shoe inlays). RESULTS: Significantly lower GAG values in patients with LLD were found (L5/S1, p = 0.02). After therapy, a trend towards higher gagCEST values in patients with LLD was observed (2.48 ± 1.77% vs. 1.79 ± 0.79%; p > 0.05). CONCLUSION: LLD represents a risk factor for molecular alterations of lumbar IVDs. Only minor effects of conservative therapy on these alterations could be found.
OBJECTIVE: Effect of conservative therapy on intervertebral discs (IVD) in patients with leg-length-discrepancy (LLD). M&M: Seventy lumbar IVDs of 14 participants (five with LLD 10-20 mm) were examined using a 3T-MRI-scanner. Morphological (Pfirrmann) and molecular (glycosaminoglycan-chemical-exchange-saturation-transfer, gagCEST) grading was assessed before and after a four-month therapy (physiotherapy and shoe inlays). RESULTS: Significantly lower GAG values in patients with LLD were found (L5/S1, p = 0.02). After therapy, a trend towards higher gagCEST values in patients with LLD was observed (2.48 ± 1.77% vs. 1.79 ± 0.79%; p > 0.05). CONCLUSION: LLD represents a risk factor for molecular alterations of lumbar IVDs. Only minor effects of conservative therapy on these alterations could be found.
Authors: C Schleich; A Müller-Lutz; K Blum; J Boos; B Bittersohl; B Schmitt; J Gerß; F Matuschke; H-J Wittsack; G Antoch; F Miese Journal: Osteoarthritis Cartilage Date: 2016-05-07 Impact factor: 6.576
Authors: Anja Müller-Lutz; Alexandra Ljimani; Julia Stabinska; Moritz Zaiss; Johannes Boos; Hans-Jörg Wittsack; Christoph Schleich Journal: MAGMA Date: 2018-05-14 Impact factor: 2.310
Authors: T K Taylor; J Melrose; D Burkhardt; P Ghosh; L E Claes; A Kettler; H J Wilke Journal: Spine (Phila Pa 1976) Date: 2000-12-01 Impact factor: 3.468
Authors: M Teraguchi; N Yoshimura; H Hashizume; S Muraki; H Yamada; A Minamide; H Oka; Y Ishimoto; K Nagata; R Kagotani; N Takiguchi; T Akune; H Kawaguchi; K Nakamura; M Yoshida Journal: Osteoarthritis Cartilage Date: 2013-11-14 Impact factor: 6.576