| Literature DB >> 29736981 |
Owen S Fenton1,2, Katy N Olafson1,2, Padmini S Pillai1,2, Michael J Mitchell3, Robert Langer1,2,4.
Abstract
Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists, and clinicians generate innovative strategies and materials to treat a range of diseases. Specifically, recent advances include major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing. Here, strategies for the design and implementation of biomaterials for drug delivery are reviewed. A brief history of the biomaterials field is first established, and then commentary on RNA delivery, responsive materials development, and immunomodulation are provided. Current challenges associated with these areas as well as opportunities to address long-standing problems in biology and medicine are discussed throughout.Entities:
Keywords: biomaterials; drug delivery; immune therapy; nanomedicine; polymers
Year: 2018 PMID: 29736981 PMCID: PMC6261797 DOI: 10.1002/adma.201705328
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849